IL: interleukin INTRODUCTION Psoriasis is a common chronic disease andmay be the most prevalent autoimmune disease. The estimated prevalence is 2% to 4% of the global population. Fortunately, providers have a plethora of medications to choose from, but even so, some cases can be very difficult to treat. Herein, we present a challenging case of palmoplantar pustulosis primarily affecting the sol...

Background: We studied the efficacy of an herbal semisolid formulation, prepared from hexane extract of seeds of Psoralea Corylifolia, which has anti-inflammatory and antimicrobial properties, in the treatment of eczema. Methods: Extraction of seeds of Psoralea Corylifolia was done in Soxhlet apparatus using hexane as the solvent. Furthermore, Oil in Water (O/W) cream was formulated with a stea...

BACKGROUND Hand eczema is the most frequently recognized occupational disease in Denmark with an incidence of approximately 0.32 per 1000 person-years. Consequences of hand eczema include chronic severe eczema, prolonged sick leave, unemployment, and impaired quality of life. New preventive strategies are needed to reduce occupational hand eczema. METHODS/DESIGN We describe the design of a ra...

Hand eczema extent was a strong negative prognostic factor in a previously published follow-up study of 868 individuals. The present aims were to study in the same cohort the association between the extent and the morphology of the hand eczema and to examine whether registering both improves the prediction of long-term prognosis. The cohort was divided into subgroups regarding eczema extent and...

BACKGROUND Severe eczema in young children is associated with an increased risk of developing asthma and rhino-conjunctivitis. In the general population, however, most cases of eczema are mild to moderate. In an unselected cohort, we studied the risk of current asthma and the co-existence of allergy-related diseases at 6 years of age among children with and without eczema at 2 years of age. M...

A 65-year-old woman with palmoplantar psoriasis was referred with intense itching eczematous dermatitis on her feet. Her history showed that she had her psoriasis treated for 3months with oral acitretin 0.5mg/kg daily and daily topical application of an emollient stick used to improve the re-epithelization of fissured heels. During the treatment, her hands healed quickly, but she experienced wo...

Lichen planus (LP) is a chronic autoimmune inflammatory dermatosis that is characterized by purple, pruritic plain topped papules, involving the skin, mucous membrane, nail and hair follicles. According to the site of involvement there are various forms of LP. Palmoplantar LP is one of the rare clinical variants, which is meanwhile accompanied with the oral involvement being extremely uncommon....

Ectodermal dysplasias are conditions that present primary defects in two or more tissues of ectodermal origin and can be classified as hypohidrotic and hidrotic. Hidrotic ectodermal dysplasia or Clouston syndrome is an autosomal dominant genodermatosis and appears as a triad of clinical findings: palmoplantar keratoderma, nail dystrophy, and hypotrichosis. The hair is sparse and brittle. The na...

Cardiac abnormalities were identified in patients with familial palmoplantar keratosis. All of them were descended from families on the Greek island of Naxos. Four families were studied and nine cases of palmoplantar keratosis were identified; seven of them showed symptoms and signs of heart disease. Cardiomegaly on chest x ray and electrocardiographic abnormalities were common findings. Three ...

We investigated the serum macrophage migration inhibitory factor (MIF) levels of palmoplantar pustulosis patients, before and after the tonsillar provocation test. Higher serum MIF levels of palmoplantar pustulosis patients were decreased after the tonsillar provocation test (n=29). To confirm these phenomena, two patients with acute tonsillitis had their changes in body temperature, C-reactive...