62 Indian Dermatology Online Journal | Volume 9 | Issue 1 | January‐February 2018 Sir, Darier disease [DD; Darier‐White disease or (dys) keratosis follicularis], is an autosomal dominant disorder of keratinization with characteristic dermatologic findings such as keratotic papules on the seborrheic regions, brittle nails and longitudinal erythronychia, and palmoplantar pitting. Hypopigmented ma...

Sir, Tegafur, a fluorinated pyrimidine analogue of 5Fluorouracil (5-FU), is metabolized in vivo with biotransformation to 5-FU (1). It is effective in the treatment of gastrointestinal carcinoma, with the advantages of low myelosuppression and lack of immunosuppression. The cutaneous adverse effects of Tegafur include stomatitis, dry skin, disseminated rash, alopecia, photosensitivity, palmopla...

A 60 year old man had asymptomatic progressive pigmentation of the palms (fig 1), fingertips (fig 2), and soles for the last 20 years. Besides this, he had discoloration of his sclerae (fig 3). He was well but for low backache and joint pains of a few months’ duration. Histopathological examination of the skin lesion was diagnostic (fig 4). Questions (1) What is your diagnosis? (2) What are the...

background & objectives:  accurate differentiation of eczema and psoriasis can be difficult, especially in areas of palm and sole. this study was designed to evaluate histopathological features and identify statistically significant parameters in distinguishing palmoplantar psoriasis from eczema of these regions in patients referring to razi skin hospital, tehran, iran. methods: in a cross-...

In a recent past, the incidence of syphilis has increased in various geographical regions. The authors describe a case of secondary syphilis mimicking palmoplantar psoriasis.

Erosive palmoplantar lichen planus (LP), also known as ulcerative or bullous LP, was first described by Cram et al. in 1966 as a rare variant of LP that can affect mucous membranes, palms, and soles. It presents clinically as erythematous, ulcerated plaques that run an extremely chronic course and are resistant to all types of treatment. The patient was an 84-year-old woman with a personal hist...