Abstract Inadequate response to antipsychotic treatment is common in patients with schizophrenia. This study evaluated pimavanserin, a 5-HT2A receptor inverse agonist/antagonist, as adjunctive inadequate response. was 6-week, randomized, double-blind, placebo-controlled, conducted North America and Europe. Adult outpatients schizophrenia current were enrolled. Inclusion criteria included Positi...

The aim of this study was to examine the relationship between childhood trauma and psychotic symptoms in schizophrenic patients after controlling for the possible confounding factors, such as depression and dissociative symptoms. Ninety-eight schizophrenic inpatients participated. Childhood trauma was examined using the Childhood Trauma Questionnaires (CTQ), which consists of physical abuse (PA...

j Abstract Objective The aim was to investigate the hypothesis that patients with first episode schizophrenic disorders have a more favorable treatment response than those with multiple episodes. Method A total of 400 inpatients from an ongoing multi-centre, follow-up program who fulfilled ICD-10 criteria for schizophrenic disorders (F2) were assessed at admission to and discharge from hospital...

Objective: Quantitative electroencephalography (QEEG) is a well established method for evaluating brain functioning. Abnormal oscillatory activity measured with QEEG during resting state has been consistently reported in patients with schizophrenia. We aimed to examine whether resting state EEG is associated with 1 year outcome in patients with first episode psychosis (FEP). Method: Twenty five...

BACKGROUND The negative symptoms of schizophrenia are not effectively treated with antipsychotic medications. Repetitive transcranial magnetic stimulation (rTMS) is an alternative approach that may be more effective in treating negative symptoms, but there has been little research comparing the effectiveness of different rTMS stimulation protocols. OBJECTIVE Compare the effect of four differe...

glutamate dysregulation may be involved in the neuropathology of schizophrenia. memantine, a drug approved by the fda for the treatment of moderate to severe alzheimer's disease, acts as a partial uncompetitive nmda receptor antagonist. the aim of this study was to examine the efficacy of memantine as an adjunctive treatment to olanzapine in patients with schizophrenia. in this double-blind, pl...

abstract background: family psycho-education is one of the most effective interventions for preventing relapse in patients with schizophrenia. we evaluated the efficacy of a needs-assessment–based educational program in comparison with a current program (textbook based) in the treatment of schizophrenia. materials and methods: patients with schizophrenia and their families (n = 60) were allocat...

After showing intermittent signs of psychosis for about 1 year, a 13-year-old boy was admitted to an inpatient psychiatric unit for increasingly bizarre behavior. The patient was experiencing typical symptoms of schizophrenia: paranoid delusions; hallucinations; fear and confusion; illogical thoughts; flat affect; and withdrawal from others. His Positive and Negative Syndrome Scale (PANSS) scor...