Several studies have shown that nitric oxide (NO) inhibits Na(+) transport in renal and alveolar monolayers. However, the mechanisms by which NO alters epithelial Na(+) channel (ENaC) activity is unclear. Therefore, we examined the effect of applying the NO donor drug l-propanamine 3,2-hydroxy-2-nitroso-1-propylhidrazino (PAPA-NONOate) to cultured renal epithelial cells. A6 and M1 cells were ma...

Nucleotide signaling networks are key to facilitate alterations in gene expression, protein function, and enzyme activity in response to diverse stimuli. Cyclic di-adenosine monophosphate (c-di-AMP) is an important secondary messenger molecule produced by the human pathogen Staphylococcus aureus and is involved in regulating a number of physiological processes including potassium transport. S. ...

Martha E. Mora-Herrera1,2, Humberto López-Delgado1, Ernestina Valadez-Moctezuma3 and Ian M. Scott4 1Programa Nacional de Papa, Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias, (INIFAP), Metepec 2Centro Universitario Tenancingo, Universidad Autónoma del Estado de México, Carr. Tenancingo-Villa Guerrero Km 1.5 Tenancingo, 3Departamento de Fitotecnia, Universidad Autónoma Ch...

PAPA IBNOU NDIAYE, JORDI MIQUEL, CARLOS FELIU and BERNARD MARCHAND Laboratori de Parasitologia, Facultat de Farmàcia, Universitat de Barcelona, Av. Joan XXIII s/n, E-08028 Barcelona, Spain Tel. +34 (93) 402-4500; Fax: +34 (93) 402-4504; email: [email protected] Laboratoire Parasites et Écosystèmes Méditerranéens, Faculté des Sciences et Techniques, Université de Corse, F-20250 Corte, F...

Introduction PAPA syndrome (Pyogenic Arthritis, Pyoderma gangrenosum, and Acne) is an ultra-rare autosomal dominant, autoinflammatory disease associated to mutations in the PSTPIP1/CD2BP1 gene. The therapeutic approach during recurrences consists of steroids, while no agreement exists on the chronic management. Evidences on the use of biologics are anecdotal and variable results have been repor...

Laboratory of Applied Microbiology, University of Applied Sciences and Arts of Southern 12 Switzerland, Bellinzona, Switzerland; bioMérieux SA, Unit Microbiology, R&D 13 Microbiology, La Balme Les Grottes, France; Department of Dermatology, University 14 Hospital of Zurich, Zurich, Switzerland; Microbiology and Virology Unit, Papa Giovanni 15 XXIII Hospital, Bergamo, Italy; POLE Pharma Consulti...

Nitric oxide is produced during intestinal inflammation and inhibits the epithelial responsiveness to cAMP-dependent secretagogues. The effect is presumably due to inhibition of activation of the CFTR. However, because insertion of CFTR into the epithelial apical membrane is also a cAMP-dependent process, we tested the hypothesis that NO could inhibit cAMP-dependent CFTR trafficking. SCBN intes...

INTRODUCTION In endeavor to suppress the cervical carcinoma there are several possible approaches including measures of primary and secondary prevention. So far effects of these measures on the number of cases and mortality rate of cervical carcinoma were modest. Only exception is organized testing based on cytological exam of the cervical smear - Pap test, which has proven to be highly effecti...

En 2010 tuvo lugar en Roma el Sínodo de Oriente Medio. Este artículo presenta los problemas, conflictos, oportunidades y esperanzas la región las comunidades cristianas Medio, su reflejo Instrumentum Laboris. Se describe desarrollo, resumiendo aportaciones del Papa, Padres Sinodales, Delegados Fraternos otras Iglesias Especiales religiones, sus reflexiones busca una respuesta espiritual, teológ...