Antipyretics, including acetaminophen (paracetamol), are prescribed commonly in children with pyrexia, despite minimal evidence of a clinical benefit. A literature review was performed by searching Medline and the Cochrane databases for research papers on the efficacy of paracetamol in febrile illnesses in children and adverse outcomes related to the use of paracetamol. No studies showed any cl...

Patients chronically abusing ethanol are more susceptible to the hepatotoxic effects of paracetamol. This could be due to an increased activation of the drug to a toxic metabolite or to a decreased capacity to detoxify the toxic metabolite by conjugation with glutathione (GSH). To test these hypotheses paracetamol 2 g was administered to five chronic alcoholics without clinical evidence of alco...

Antipyretics, including acetaminophen (paracetamol), are prescribed commonly in children with pyrexia, despite minimal evidence of a clinical benefit. A literature review was performed by searching Medline and the Cochrane databases for research papers on the efficacy of paracetamol in febrile illnesses in children and adverse outcomes related to the use of paracetamol. No studies showed any cl...

Objectives: In this present study the hepatoprotective effect of an optimized herbal formula (HF) was appraised against paracetamol induced liver damage in rats. Methods: In vitro antioxidant activity HF evaluated by ABTS radical scavenging assay. The (100, 200 and 400 mg/kg b.w) assessed Serum enzymatic levels serum glu...

Abbreviations: ALT, alanine aminotransferase; APAP, acetaminophen; CoQ10, oxidized coenzyme Q10; CoQ9H2, reduced coenzyme Q9; CoQ10H2, reduced coenzyme Q10; CYP, cytochrome P450; GSH, reduced glutathione; GSSG, oxidized glutathione; HSP, heat shock protein; MEOS, microsomal ethanol oxidizing system; NAC, N-acetylcysteine; NAPQI, N-acetyl-p-benzoquinoneimine; ROS, reactive oxygen species; SAMC, ...