Fluorochinolones are a class of broad-spectrum antimicrobials in the treatment of several infections, including those caused by Escherichia coli. Due to the increasing resistance of bacteria to antimicrobials, an understanding of fluoroquinolone resistance is important for infection control. The aim of this study was to determine susceptibility of clinical E. coli strains to fluoroquinolones an...

To evaluate the molecular mechanism of fluoroquinolones resistance in Mycoplasma hominis (MH) clinical strains isolated from urogenital specimens. 15 MH clinical isolates with different phenotypes of resistance to fluoroquinolones antibiotics were screened for mutations in the quinolone resistance-determining regions (QRDRs) of DNA gyrase (gyrA and gyrB) and topoisomerase IV (parC and parE) in ...

The search for sterile neutrinos is one of the hottest topics in the neutrino physics in this decade. The JSNS2 (J-PARC Sterile Neutrino Search at the J-PARC Spallation Neutron Source) experiment aims to search for the existence of neutrino oscillations with ∆m2 near 1eV2 at the J-PARC Materials and Life Science Experimental Facility (MLF). With the 1 MW of 3 GeV proton beam created by Rapid Cy...

Fluoroquinolone resistance in Streptococcus pneumoniae is primarily mediated by point mutations in the quinolone resistance-determining regions of gyrA and parC. Antimicrobial resistance mutations in housekeeping genes often decrease fitness of microorganisms. To investigate the fitness of quinolone-resistant S. pneumoniae (QRSP), the relative growth efficiencies of 2 isogenic QRSP double mutan...

Cholera has reinstated its deadly grip on the planet with recent epidemics in Zimbabwe and Haiti (1, 2), along with the emergence of Vibrio cholerae having reduced susceptibility to fluoroquinolones. India also experiences frequent outbreaks caused by multidrug-resistant V. cholerae (3). We report reduced sensitivity to ciprofloxacin in V. cholerae O1 El Tor Ogawa and novel multiple mutations i...

The in-vitro antimicrobial activity of HSR-903, a new fluoroquinolone, was tested against 51 clinical Neisseria gonorrhoeae isolates in comparison with ciprofloxacin, levofloxacin and sparfloxacin. The MICs of HSR-903 for 11 isolates with alterations in both GyrA and ParC, for 19 isolates with alterations only in GyrA and for 21 isolates without alterations in either GyrA or ParC ranged from 0....

Marian Garcia-Nuñez, Laura Millares, Xavier Pomares, Rafaela Ferrari, Vicente Pérez-Brocal, Miguel Gallego, Mateu Espasa, Andrés Moya, Eduard Monsó Fundació Parc Taulí, Sabadell/Badalona, Spain; CIBER de Enfermedades Respiratorias, CIBERES, Bunyola, Spain; Universitat Autònoma de Barcelona, Esfera UAB, Barcelona, Spain; Fundació Institut d’Investigació Germans Trias i Pujol, Badalona, Spain; Ge...

2 The Asia/Pacific Research Center (A/PARC) is an important Stanford venue, where faculty and students, visiting scholars, and distinguished business and government leaders meet and exchange views on contemporary Asia and U.S. involvement in the region. A/PARC research results in seminars and conferences, published studies, occasional and discussion papers, special reports, and books. A/PARC ma...