Post kala-azar dermal leishmaniasis (PKDL) is a skin manifestation that usually develops after treatment of visceral leishmaniasis (VL), a major public health problem in India. The diagnosis and management of PKDL is complex. This is the first case report from India in which PKDL occurred after paromomycin treatment for VL in an Indian patient.

Communications The aminoglycosides apramycin (yellow) and paromomycin (green) exploit different binding spaces at their target ribosomal decoding-site RNA although they share a common 2-deoxystreptamine scaffold (white center). More about these studies on molecular recognition can be found in the Communication by T. Hermann and co-workers on the following pages.

Six partially dominant antisuppressors were obtained that reduce the efficiency of two omnipotent yeast suppressors, sup45 and sup35, thought to be ribosomal ambiguity mutations. Each of these six antisuppressors was shown to fall within a single Mendelian locus, named asu9. The asu9 mutations are specific for omnipotent suppressors; they have no effect on several dominant tRNA-like suppressors...

Abstract We unveil in this work the main factors that govern turn‐on/off fluorescence of a Se‐modified uracil probe at ribosomal RNA A‐site. Whereas constraint into an “in‐plane” conformation two rings fluorophore is driver for observed turn‐on emission presence antibiotic paromomycin, electrostatics environment plays minor role during process. Our computational strategy clearly indicates that,...

Paromamine1>2) is a common and antibacterial moiety of paromomycin I and II, and kanamycin C, and was recently isolated3) from a crude kanamycin-complex. The synthesis4) had already been achieved in our laboratory through the condensation of bis-N,N/-(2,4-dinitrophenyl)-2-deoxystreptamine with 3,4,6-tri-O-acetyl-2-deoxy-2-(2,4dinitroanilino)-^-D-glucopyranosyl bromide. This paper describes an i...