Rapidly progressive Kaposi sarcoma (KS) lesions with lymphadenopathy and tissue swelling occurred in a patient during antiretroviral treatment, despite an increased CD4(+) lymphocyte count and decreased HIV-1 level and KS-associated herpesvirus replication, suggesting immune reconstitution inflammatory syndrome. Inflammation resolved coincident with decreases in the CD4(+) lymphocyte count duri...

A child with ambiguous genitalia, brought up phenotypically male, had a 46,XX/46,XY karyotype. At laparotomy, he had a left sided ovary and uterus, and a right sided scrotal testis. The 46,XX line made up 50% of cells in the blood and 90% of cells in a skin biopsy. There were no cytogenetic polymorphisms. Analysis of lymphocyte DNA with seven polymorphic DNA markers showed him to be chimaeric, ...

Estimation of T-lymphocyte subsets continues to be an important aspect for monitoring HIV disease progression and response to antiretroviral therapy. Most of the diagnostic laboratories often rely on studies from western for CD4+T-lymphocyte reference values, which could, often be unreliable for usage in local settings. To establish the normal reference values of T lymphocyte subsets from healt...

Exposing male mice to nicotine or cocaine enables their male offspring to cope with high doses of either, which suggests that such paternal effects are generic, rather than being a response to a specific type of stress.

PURPOSE The present study aimed to examine the clinical implications of CD4, CD8, and FOXP3 expression on the prognosis of human epidermal growth factor receptor 2 (HER2)-positive breast cancer using a web-based database, and to compare the immunohistochemical expression of T-lymphocyte markers using primary and metastatic HER2-positive tumor tissues before and after HER2-targeted therapy. ME...

Background: The aetiology of recurrent pregnancy loss (RPL) is varied and ranges from genetic abnormalities, autoimmune, uterine structural thrombophilic disorders, endocrinologic dysfunction, infective to idiopathic factors. Reproductive immunology may provide an area opportunity in treatment cases. Research has indicated that any amount HLA compatibility among spouses leads immunological pert...

During summer, female meadow voles (Microtus pennsylvanicus) maintain territories and males do not engage in paternal care. As day length shortens, territories dissolve and males nest with females and young. Because paternal behavior has never been studied in free-living meadow voles during colder months or in the laboratory under short photoperiods, the authors examined whether males housed in...

Since half of the genes are inherited from paternal side, maternal immune system has to tolerate presence foreign antigens. Regulatory T cells facilitate development and maintenance peripheral tissue tolerance fetus during pregnancy. Reduction in regulatory is associated with complications pregnancy, including spontaneous abortion. Recent studies mouse models have shown that adoptive transfer T...

Submit Manuscript | http://medcraveonline.com Abbreviations: ALL: Acute Lymphoblastic Lymphoma; BLA: Biologics License Application; CAR: Chimeric Antigen Receptor; CD19: Specific Antigen; CBER: Center for Biologics Evaluation and Research; CHOP: Children’s Hospital of Philadelphia; CLL: Chronic Lymphocytic Leukemia; CRS: Cytokine Release Syndrome; CTLA: Cytotoxic T-Lymphocyte Antigen; DNA: Deox...