A 43-MDa conjugative plasmid isolated from an avian septicemic Escherichia coli (APEC) strain possessing genes related to the adhesion and invasion capacities of in vitro-cultured cells was sequenced. The results demonstrated that the 43-MDa plasmid harbors bacterial pathogenicity-related sequences which probably allow the wild-type pathogenic strain to adhere to and invade tissues and to cause...

Listeriolysin O (LLO) and ActA are essential virulence determinants for Listeria monocytogenes pathogenesis. Transcription of actA and hly , encoding LLO, is regulated by PrfA and increases dramatically during intracellular infection. The 5 ¢ untranslated regions (5 ¢ UTRs) of actA and prfA have been shown to upregulate expression of their respective gene products. Here, we demonstrate that the...

Apoptosis triggered by exogenous and endogenous stimuli such as ultraviolet radiation, oxidative stress, and genotoxic chemicals is a crucial phenomenon within biological systems. DNA damage activates and stabilizes p53 in nucleus and cytoplasm and regulates other proteins that stimulate intrinsic and extrinsic apoptotic pathways. Apoptosis is morphologically distinct from that of necrosis and ...

Pathogenic bacteria utilise a number of mechanisms to cause disease in human hosts. Bacterial pathogens express a wide range of molecules that bind host cell targets to facilitate a variety of different host responses. The molecular strategies used by bacteria to interact with the host can be unique to specific pathogens or conserved across several different species. A key to fighting bacterial...

The polymorphic fungus Candida albicans is a member of the normal human microbiome. In most individuals, C. albicans resides as a lifelong, harmless commensal. Under certain circumstances, however, C. albicans can cause infections that range from superficial infections of the skin to life-threatening systemic infections. Several factors and activities have been identified which contribute to th...

Avian influenza viruses (AIV) and Newcastle disease viruses (NDV) of high pathogenicity cause severe systemic disease with high mortality in chickens and can be isolated from the meat of infected chickens. Although AIV and NDV strains of low pathogenicity are typically not present in chicken meat, virus particles in respiratory secretions or feces are possible sources of carcass contamination. ...

Ascochyta blight is a major biotic constraint of faba bean (Vicia L.) production and productivity worldwide caused by fabae. No studies have been performed in Algeria to identify A. fabae isolates or assess their pathogenicity, therefore information on local insufficient. Herein, 14 were obtained from samples identified based morphological traits phylogenetic analysis internal transcribed space...

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abstract ascochyta blight caused by didymella rabiei is one of the most important diseases of chickpea in ilam and kermanshah provinces, iran. in order to determine the pathogenicity variation of didymella rabiei populations, infected plants in field crops of different regions of both provinces were sampled. one hundred isolates were isolated by chickpea seed meal dextrose agar media. these iso...