Paul Conduit was a research assistant in John Kilmartin's lab at the MRC/LMB in Cambridge, UK, before beginning his PhD in 2006 with Jordan Raff. In 2010 he moved with Jordan from the Gurdon Institute in Cambridge to the University of Oxford, where he continued his work as a postdoctoral fellow. Paul is now a Sir Henry Dale Wellcome Fellow at the University of Cambridge and has been a group lea...

Abstract. Active subspaces can effectively reduce the dimension of high-dimensional parameter studies enabling otherwise infeasible experiments with expensive simulations. The key components of active subspace methods are the eigenvectors of a symmetric, positive semidefinite matrix whose elements are the average products of partial derivatives of the simulation’s input/output map. We study a M...

Wolbachia is an endosymbiont of diverse arthropod lineages that can induce various alterations of host reproduction for its own benefice. Cytoplasmic incompatibility (CI) is the most common phenomenon, which results in embryonic lethality when males that bear Wolbachia are mated with females that do not. In the cherry fruit fly, Rhagoletis cerasi, Wolbachia seems to be responsible for previousl...

1* Atomicity is a necessary element for reliable transactions (Financial Service Technology Consortium, 1995; Camp, Sirbu and Tygar, 1995; Tygar, 1996). Anonymity is also an issue of great importance not only to designers of commerce systems, (Chaum, 1982; Chaum, 1989; Chaum, Fiat & Naor, 1988; Medvinski, 1993), but also to those concerned with the societal effects of information technologies (...

Portfolio implementation is critical for investment success. Seemingly minor differences in portfolio construction can lead to major differences in performance outcomes. In this paper, we summarize the differences between two popular portfolio construction approaches, “mix” and “integrate,” and examine a handful of value and momentum-themed examples to demonstrate how these differences play out...

Table of Contents Foreword 1 1. Why use control groups in impact assessments of microfinance projects? 3 2. Biases of the control-group method and how to avoid them 7 2.1 Sample selection bias 7 2.2 Misspecification of underlying causal relationships 9 2.3 Motivational problems 10 3. Conclusions and recommendations 15 General recommendations 18 Recommendations for evaluators and donors 18 Recom...