Viscoelastic properties of the highly filled plastic-bonded explosive PBX-9501 were studied by two-dimensional dynamic Material Point Method (MPM) simulations. The upper and lower bounds for the composite properties were estimated from iso-displacement and iso-stress boundary conditions. A homogenized or “dirty” binder approach was utilized to handle the multiple length scales involved in MPM s...

INTRODUCTION Planarians are capable of regenerating any missing body part and are an emerging system for investigation of cellular and molecular mechanisms underlying regeneration. Regeneration requires production of new cells and instructions that specify the identity of cell types to be regenerated. The planarian Schmidtea mediterranea utilizes a population of dividing regenerative cells call...

Numerical simulations of the heating with constant rate of a PBX plastic-bonded explosive 9501 formulation consisting of the energetic crystal HMX embedded in a polymeric binder inside of a rigid cylinder is performed. The continuum thermo-mechanochemical model of the behavior of a PBX 9501 developed in the preceding paper V. I. Levitas, B. F. Henson, L. B. Smilowitz, D. K. Zerkle, and B. W. As...

Pre-B-cell leukemia homeobox (PBX) and myeloid ecotropic viral integration site (MEIS) proteins control cell fate decisions in many physiological and pathophysiological contexts, but how these proteins function mechanistically remains poorly defined. Focusing on the first hours of neuronal differentiation of adult subventricular zone-derived stem/progenitor cells, we describe a sequence of even...

As wireless technology advances, wireless products are integrated with enterprise networking to offer cordless terminal mobility. Most corporations have deployed wireless PBXs at the departmental level. However, the mobility management mechanism that integrates these facilities at the corporation level may not be available. This paper describes a mobility management mechanism for an enterprise ...

Comparison of Hoxb-1 regulatory regions from different vertebrates identified three related sequence motifs critical for rhombomere 4 (r4) expression in the hindbrain. Functional analysis in transgenic mice and Drosophila embryos demonstrated that the conserved elements are involved in a positive autoregulatory loop dependent on labial (lab) family members. Binding of Hoxb-1 to these elements i...

Hox transcription factors (TFs) are essential for vertebrate development, but how these evolutionary conserved proteins function in vivo remains unclear. Because Hox proteins have notoriously low binding specificity, they are believed to bind with cofactors, mainly homeodomain TFs Pbx and Meis, to select their specific targets. We mapped binding of Meis, Pbx, and Hoxa2 in the branchial arches, ...