Pathogenic mutations in leucine-rich repeat kinase 2 (LRRK2; PARK8) have been implicated in autosomal dominant, late-onset Parkinson's disease (PD). The LRRK2 4321C>G (R1441G) mutation was originally identified in Spanish families originating from the Basque region. Within this ethnicity, Lrrk2 R1441G substitutions have been suggested as a frequent cause of disease. Herein we have assessed anot...

The [3 + 2] cycloaddition of azides and acetylenes followed by nitrogen quaternization was applied for the generation of novel and highly modular triazolium salts. The selective substitution of the 1,3,4-substitution pattern presets such salts as precursors for a new class of abnormal carbene ligands, thus expanding the family of these high-impact ligands. Metalation of the triazolium salts is ...

A series of boron dipyrromethene (BODIPY) dyes was tested as photosensitisers for light-driven hydrogen evolution in combination with the complex [Pd(PPh3)Cl2]2 as a source for catalytically-active Pd nanoparticles and triethylamine as a sacrificial electron donor. In line with earlier reports, halogenated dyes showed significantly higher hydrogen production activity. All BODIPYs were fully cha...

Impairment of attention and memory in patients with Alzheimer's disease (AD) is associated with significantly lower levels of acetylcholine. Inhibition of the breakdown of acetylcholine by blocking the enzymes acetylcholinesterase and butyrylcholinesterase with rivastigmine improves this cholinergic depletion. Thus rivastigmine administration provides established, effective, long-term symptomat...

The behavior of the so-called weak moment antiferromagnetic states, observed in the heavy-fermion superconductors UPt3 and URu2Si2, is discussed in view of recent μSR results obtained as function of control parameters like chemical substitution and external pressure. In UPt3, the Pd substitution for Pt reveals the dynamical character of the weak moment order. On the other hand, μSR measurements...

Mutations in Park8, encoding for the multidomain Leucine-rich repeat kinase 2 (LRRK2) protein, comprise the predominant genetic cause of Parkinson's disease (PD). G2019S, the most common amino acid substitution activates the kinase two- to threefold. This has motivated the development of LRRK2 kinase inhibitors; however, poor consensus on physiological LRRK2 substrates has hampered clinical dev...

Thanks to the onio-substitution strategy, tricationic imidazolium salt (1·H)(OTf)3 featuring two N-cyclopropenio substituents was readily prepared in a two-step procedure from 1H-imidazole. The influence of cyclopropenium moieties on electronic properties related dicationic NHC 12+ evaluated basis 1JCH, δ 77Se, and Tolman parameter (TEP) values obtained, respectively, precursor (1·H)(OTf)3, NHC...

We report a doping study directed to intentionally induce disorder in ${\mathrm{PdTe}}_{2}$ by the isoelectronic substitution of Pt. Two single-crystalline batches ${\mathrm{Pd}}_{1\ensuremath{-}x}{\mathrm{Pt}}_{x}{\mathrm{Te}}_{2}$ have been prepared with nominal concentrations $x=0.05$ and $x=0.10$. Sample characterization energy dispersive x-ray spectroscopy revealed Pt did not dissolve homo...