Osteoporosis, associated with low BMD, is a public health problem. Peak bone mass (PBM) is influenced by genetics, nutrition, body weight and physical activity, with 90% of PBM obtained by age 18 years. Recent research challenges the belief that obesity protects against low BMD. In a study of overweight and obese adults, researchers noted that overweight status was neutral or protective of BMD,...

1 ABSTRACT: Osteoporosis is a gradual reduction in bone mass that leads to an increased susceptibility to bone fractures. An estimated 1.5 million fractures are attributed to osteoporosis each year in the United States. With the rapid aging of the population, the suffering and healthcare costs associated with osteoporosis are steadily increasing. Experts agree that prevention is the most effect...

Peak bone mass (PBM) reaching 80-90 percent in late adolescence, it is a major determinant of bone mass later in life. Prevention of osteoporosis should start early in life, before PBM is reached. Puberty has varying effects on skeletal mineralization depending on the skeletal site and changes in hormone concentration of different bones. Vitamin D and calcium have been recognized as potential c...

Adults with beta thalassemia major frequently have low BMD, fractures, and bone pain. The purpose of this study was to determine the prevalence of low BMD, fractures, and bone pain in all thalassemia syndromes in childhood, adolescence, and adulthood, associations of BMD with fractures and bone pain, and etiology of bone disease in thalassemia. Patients of all thalassemia syndromes in the Thala...

Loeys-Dietz syndrome (LDS) is a rare autosomal-dominant connective tissue disorder caused by heterozygous mutations in the genes encoding transforming growth factor beta receptor 1 or 2 (TGFBR1 or TGFBR2). Although an association between LDS and osteoporosis has been reported, the skeletal phenotype regarding bone mass is not well characterized. Here, we report on two LDS patients with mutation...

BACKGROUND Very-low-birth-weight (VLBW, <1,500 g) infants have compromised bone mass accrual during childhood, but it is unclear whether this results in subnormal peak bone mass and increased risk of impaired skeletal health in adulthood. We hypothesized that VLBW is associated with reduced bone mineral density (BMD) in adulthood. METHODS AND FINDINGS The Helsinki Study of Very Low Birth Weig...

Ca is the major mineral in bone, and 99% of the Ca in the body resides in the skeleton. Skeletal mass is a determinant of risk of fracture in childhood as well as adulthood. Over 40% of adult peak bone mass is acquired during adolescence. This period is when lifestyle choices, including ensuring adequate dietary Ca, regular weight-bearing exercise and avoiding hormonal insufficiency, are especi...

Background Improving peak bone mass and bone strength in the first years of life and enhancing it during young adulthood could prevent osteoporosis and fractures in the last years of life. We evaluated the prevalence of low bone mass in the lumbar and femoral neck and its associated factors in southern Iranian children. Methods This is a cross-sectional study on healthy Iranian children aged ...

OBJECTIVE The link between central adiposity and osteopenia has not been extensively studied in Latina women. In particular, the association between abdominal weight and bone mineral content (BMC) and bone mineral density (BMD), independent of total weight and aerobic capacity, remains uncertain, especially in overweight and obese individuals. METHODS Trunk weight, total body fat mass, fat-fr...