Despite improved endotracheal tube designs, aspiration remains a cause of pulmonary complications. This in vitro study evaluates the efficacy of positive end-expiratory pressure (PEEP) in reducing the incidence of seepage around endotracheal tubes during mechanical (MV) and spontaneous ventilation (SV). Two transparent plastic "tracheas" with cuffed and uncuffed endotracheal tubes simulated adu...

Positive end-expiratory pressure (PEEP) applied during induction of anesthesia prevents atelectasis formation and increases the duration of nonhypoxic apnea in nonobese patients. PEEP also prevents atelectasis formation in morbidly obese patients. Because morbidly obese patients have difficult airway management more often and because arterial desaturation develops rapidly, we studied the clinic...

Phasic bursting in the hypoglossal nerve can be uncoupled from phrenic bursting by application of positive end-expired pressure (PEEP). We wished to determine whether similar uncoupling can also be induced in other respiratory-modulated upper airway (UAW) motor outputs. Discharge of the facial, hypoglossal, superior laryngeal, recurrent laryngeal, and phrenic nerves was recorded in anesthetized...

1320 December 2014 H YPOXEMIA is a commonly encountered problem in mechanically ventilated patients. Treatment of hypoxemia relies on the titration of FIO2 and positive end-expiratory pressure (PEEP) to optimize PaO2. Modern ventilation strategies aimed at minimizing lung injury while simultaneously managing hypoxemia have improved mortality in respiratory failure, but the ideal strategy for lu...

BACKGROUND AND PURPOSE We undertook this study to evaluate the influence of positive end-expiratory pressure (PEEP) on intracranial pressure (ICP) and cerebral perfusion pressure (CPP) in patients with acute stroke. METHODS A total of 20 ventilated patients of a neurological intensive care unit were examined under a protocol entailing variation of PEEP to 4, 8, 12, and 4 mm Hg; mean arterial ...

INTRODUCTION As it becomes clear that mechanical ventilation can exaggerate lung injury, individual titration of ventilator settings is of special interest. Electrical impedance tomography (EIT) has been proposed as a bedside, regional monitoring tool to guide these settings. In the present study we evaluate the use of ventilation distribution change maps (DeltafEIT maps) in intensive care unit...

OBJECTIVE Evaluate the effects of continuous positive airway pressure (CPAP)/positive end-expiratory pressure (PEEP) and pressure support ventilation (PSV) on work of breathing (WOB). METHODS With 13 anesthetized lambs we measured WOB with an esophageal balloon and flow signals. All the animals were sedated, intubated, and ventilated, using 2 pediatric ventilators (Servo 300 and VIP Bird). Ve...

INTRODUCTION Intra-abdominal hypertension (IAH) causes atelectasis, reduces lung volumes and increases respiratory system elastance. Positive end-expiratory pressure (PEEP) in the setting of IAH and healthy lungs improves lung volumes but not oxygenation. However, critically ill patients with IAH often suffer from acute lung injury (ALI). This study, therefore, examined the respiratory and card...

in various lung units based on the lung mechanics of the unit. Lung units with long time constants (high airway resistance and/or high compliance) always develop the greatest auto-PEEP, whereas lung units with the shortest time constants (low compliance and/or low resistance) always develop the least auto-PEEP. As shown in the mathematical discussion by Chatburn and Kallet, lung units that are ...