Millions of people experience consequential tooth loss related to irretrievable damage of the periodontium caused by deep caries, severe periodontal diseases or irreversible trauma, resulting in a decreased quality of life. Hence, dental scientists have focused much attention on tissue engineering techniques in an effort to address this condition. The periodontium is composed mainly of two soft...

BACKGROUND AND OBJECTIVE Platelet-rich plasma is used to deliver growth factors, in a safe and convenient manner, for enhancing bone and periodontal regeneration. However, conflicting reports regarding its effectiveness suggest that further study of the relevant cellular mechanisms is required. The aim of this study was to investigate the in vitro effect of platelet-rich plasma on osteoblasts a...

Enamel matrix derivative (EMD), a porcine extract harvested from developing porcine teeth, has been shown to promote formation of new cementum, periodontal ligament and alveolar bone. Despite its widespread use, an incredibly large variability among in vitro studies has been observed. The aim of the present study was to determine the influence of EMD on cells at different maturation stages of o...

In order to provide the best long-term prognosis for a tooth that is to be replanted intentionally, the tooth must be kept out of the socket for the shortest period possible [4], and the extraction of the tooth should be atraumatic to minimise damage to the cementum and the periodontal ligament [5]. The periodontal ligament attached to the root surface should be kept moist in saline, Hank’s Buf...

Background: Stem cells have been widely used in various fields of the health sector, one which is dental health. Teeth with malocclusion require orthodontic treatment to achieve good function and aesthetics. Orthodontic tooth movement (OTM) occurs due a bone remodeling process, namely deposition areas tension resorption pressure. Differentiated stem are thought influence OTM through several dif...

Peripheral ossifying fibroma is a common solitary gingival overgrowth thought to arise from the gingival corium, periosteum or periodontal ligament. Ossifying fibroma has the propensity to occur in cranial bones, but the peripheral variety shows a close relationship with the periodontal ligament and adjacent alveolar bone. It is more commonly seen in women (predilection of 3:1) and usually at a...

In our previous studies, we developed the normal periodontal ligament index (nPLI) and the residual periodontal ligament index (rPLI), to estimate residual periodontal ligament support for individual teeth during treatment planning for partially edentulous patients. The purpose of the current in vitro study was to analyze tooth mobility resulting from periodontal attachment loss, and to determi...

Numerous animal and human studies have provided evidence supporting the belief that periodontal ligament stem cells (PDLSCs) can be harnessed for regeneration of periodontal tissues. Based on current literature on the use of ex vivo stem culture and associated problems, this case report describes a novel approach of direct application PDLSCs using stem cell assistance in periodontal regeneratio...

Periodontal diseases are characterized by alveolar bone absorption and destruction of periodontal ligament and cementum and are the main causes of tooth loss in adults. This series of diseases is harmful to both human oral and body health. Although periodontitis is under control because of the implementation of conventional treatment modalities, regenerating damaged periodontal tissues remains ...