Aim: Fibrin sealant is a biological tissue adhesive mimicking the final stage of coagulation. It has a wide variety of application in the field of periodontics. The aim of this article was to review current applications and identify potential use of fibrin sealant in periodontal surgical procedures on an evidence-based conclusion. Materials and methods: An online search was performed in PubMed,...

Although defect or defect morphology continue to prevail as the basis for treatment in current periodontology, diagnosis must be the basis for periodontal therapy (20). The periodontal therapist should aim at eliminating the causative and contributing factors of the disease. Based on diagnosis, the integration of reparativeproceduresmayleadtodefinitivetreatment,which canhelpmaintaintherapeuticr...

We recently developed novel cell transplantation method "cell transfer technology" utilizing photolithography. Using this method, we can transfer ex vivo expanded cells onto scaffold material in desired patterns, like printing of pictures and letters on a paper. We have investigated the possibility of this novel method for cell-based therapy using several disease models. We first transferred en...

Complete reconstruction of damaged periodontal pockets, particularly regeneration of periodontal ligament (PDL) has been a significant challenge in dentistry. Tissue engineering approach utilizing PDL stem cells and scaffolding matrices offers great opportunity to this, and applying physical and mechanical cues mimicking native tissue conditions are of special importance. Here we approach to re...

Regenerative periodontal therapy aims at reconstitution of the lost periodontal structures such as new formation of root cementum, periodontal ligament and alveolar bone. Findings from basic research indicate that enamel matrix protein derivative (EMD) has a key role in periodontal wound healing. Histological results from animal and human studies have shown that treatment with EMD promotes peri...

Periodontists have been experimenting various modalities for regeneration in Aggressive periodontitis with varying degrees of success. Periodontal surgery along with platelet rich fibrin (PRF) has yielded promising results. The purpose of this clinical trial was to evaluate the surgical outcome of an autologous growth factor obtained by sequestering and concentrating platelets by gradient densi...

This Special Issue entitled "Soft and Hard Tissue Regeneration" will cover both periodontal and implant therapies.[...].

Periodontal disease causes tooth loss by destroying the attachment system and supporting tissues. therapy seeks to not only halt advancement of periodontal disease, but also repair lost structures caused progression. Extracellular matrix (ECM) is a complex three-dimensional network made up an array multidomain macromolecules organised in cell/tissue-specific manner that serves as structural sca...

background: periodontal ligament stem cells (pdlscs) are considered as a type of mesenchymal stem cell that is beneficial target for numerous clinical applications in periodontal tissue regeneration therapy. materials and methods: this study examined the effects of dexamethasone (dex) on human pdlscs in vitro. pdlscs obtained from the roots of patient’s teeth were cultured with dex (0.01 μm), a...

Both periodontal ligament and gingival tissue are thought to harbor cells with the ability to stimulate periodontal regeneration, i.e., formation of new bone, cementum, and connective tissue attachment. To understand further the role of these cells in the regenerative process, we compared human periodontal ligament cells and gingival fibroblasts, both derived from the same patient, same passage...