نتایج جستجو برای: peripheral ischemia
تعداد نتایج: 262699 فیلتر نتایج به سال:
BACKGROUND AND AIM Allow for protection of briefly ischemic tissues against the harmful effects of subsequent prolonged ischemia is a phenomenon called as Ischemic Preconditioning (IP). IP has not been studied in ischemia-reperfusion (I/R) model of peripheral nerve before. We aimed to study the effects of acute IP on I/R injury of peripheral nerve in rats. METHOD 70 adult male rats were rando...
Nerve ischemia, both acute and chronic, may contribute to diabetic neuropathies, but the pathogenesis remains obscure. The vulnerability of diabetic nerve to ischemia was assessed by ligating arteries of supply of rat sciatic nerve after 20 wk of streptozocin-induced diabetes. In the first 24 h after the arterial ligations, severe and more rapidly occurring clinicopathological abnormalities wer...
BACKGROUND Human tissue kallikrein (HK) releases kinins from kininogen. We investigated whether adenovirus-mediated HK gene delivery is angiogenic in the context of ischemia. METHODS AND RESULTS Hindlimb ischemia, caused by femoral artery excision, increased muscular capillary density (P:<0.001) and induced the expression of kinin B(1) receptor gene (P:<0.05). Pharmacological blockade of B(1)...
Buerger disease or thromboangiitis obliterans is a non-atherosclerotic, segmental, inflammatory, peripheral arterial occlusive in young male smokers. Revascularization via endovascular treatment and/or bypass surgery less common and technically challenging patients with disease. Herein, we report the case of 30-year-old patient who underwent followed by surgery, which successfully salvaged his c...
Deficient angiogenesis following ischemia may contribute to worse outcomes of peripheral arterial disease in patients with diabetes mellitus (DM). Vascular endothelial growth factor (VEGF) and its receptors promote angiogenesis. We hypothesized that in peripheral arterial disease, maladaptive changes in VEGF ligand/receptor expression could account for impaired angiogenesis in DM. Skeletal musc...
BACKGROUND AND PURPOSE Polyamines are mainly restricted to the intracellular space. During focal cerebral ischemia, polyamines are released from the intracellular compartment. Experimental studies have implicated a marked elevation in brain tissue and blood. The aim of our study was to investigate whether the elevation of polyamines in the blood of patients with focal cerebral ischemia correlat...
Deficient angiogenesis after ischemia may contribute to worse outcomes of peripheral arterial disease in patients with diabetes mellitus (DM). Vascular endothelial growth factor (VEGF) and its receptors promote angiogenesis. We hypothesized that in peripheral arterial disease, maladaptive changes in VEGF ligand/receptor expression could account for impaired angiogenesis in DM. Skeletal muscle f...
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