The pharmacokinetics of pegylated liposomal doxorubicin (PLD) were investigated in 17 women undergoing intraoperative hyperthermic intraperitoneal chemotherapy (HIPEC) for advanced ovarian cancer and peritoneal carcinomatosis. HIPEC was performed immediately after completing debulking surgery, which included a number of peritonectomy procedures. PLD was injected and allowed to equilibrate in pe...

BACKGROUND By virtue of their high net negative charge, glycosaminoglycans and proteoglycans play pivotal roles in biologic processes such as cell-cell and cell-matrix interactions, sequestration of growth factors, activation of chemokines and cytokines, and permselectivity of basement membranes. METHODS The present article reviews the putative roles of glycosaminoglycans and proteoglycans in...

Presence of mast cell precursors in the mouse peritoneal cavity was demonstrated, and the precursors were characterized. When a cell suspension, containing mast cell precursor(s), was directly injected into the skin of genetically mast cell-deficient WBB6F1 (WB X C57BL/6)-W/Wv mice, a cluster composed of approximately 2,000 mast cells appeared at the injection site. By determining the proportio...

in our experimental study, 48 rats were divided into six groups in a randomized manner: a (1-3) and b (1-3) groups. a1 and b1 were negative controls. laparotomy was performed and peritoneal inflammation on exposed bowel and peritoneum in a (1-3) and experimental infection induced in peritoneal cavity of b (1-3). each rat of a2 and b2 received 100 iu intraperitoneal standard heparin and each rat...

hydatid disease, caused by echinococcusgranulosus, is a common parasitic infection of the liver. disseminated intra-abdominal hydatid disease may occur with the rupture of the hydatid cyst into the peritoneal cavity, producing secondary echinococcosis. but primary hydatid cyst in the pelvis is rare. we report a case of bilateral hydatid cyst of the pelvis in a 53years old woman presented with a...

Intraperitoneal therapies such as peritoneal dialysis or regional chemotherapy use large volumes of solution within the peritoneal cavity. These volumes increase intraperitoneal hydrostatic pressure (P(ip)), which causes flow of the solution into tissues that surround the cavity. The goal of this paper is to integrate new experimental findings in a rigorous mathematical model to predict protein...

The magnitude of peritoneal lymph flow is an issue of great controversy in peritoneal dialysis (PD) research. Because no single lymphatic duct drains the entire peritoneal cavity, peritoneal lymph flow is indirectly measured as lymphatic removal of intraperitoneal macromolecular tracer. In rats, the peritoneal clearance (K) of such a tracer is 5 times the approximately 8 microL/min determined f...

three-year-old boy came to emergency room of soraya medical center with abdominal pain, nausea, vomiting and distended abdomen for a period of three days. x-ray showed fluid in the peritoneal cavity and at pleural space, mild elevation of the hemi diaphragm, and thick left diaphragm. surgery showed sub diaphragmatic abscess under in the hemi diaphragm and peritonitis. the autopsy showed several...

63 Background: Peritoneal metastasis is considered to develop from carcinoma cells detached from the serosal surface of the primary site and dispersed in the peritoneal cavity. And oxygen is one of the most important environmental factors for tumor development. To investigate the oxygenation condition in the abdominal cavity, that is largely unknown, we collected ascitic fluid from patients wit...

We present an unusual case of peritoneal catheter migration following a ventriculoperitoneal shunt operation. A 7-month-old infant, who had suffered from intraventricular hemorrhage at birth, was shunted for progressive hydrocephalus. The peritoneal catheter, connected to an 'ultra small, low pressure valve system' (Strata®; PS Medical,Gola, CA, USA) at the subgaleal space, was placed into the ...