Xanthelasma palpebrarum is the most common cutaneous xanthoma, characterized by yellowish plaques over eyelids - most commonly, over the inner canthus of the upper lid. It is triggered by hyperlipidemia, thyroid dysfunction, and diabetes mellitus. Xanthelasma results from perivascular infiltration of mono- and multinucleated foam cells within lipid-laden cytoplasmic vacuoles in the superficial ...

Telangiectasia macularis multiplex acquisita (TMMA) is a rarely documented disease entity that usually occurs in the middle-aged men. A 68-year-old man presented with asymptomatic erythematous-brownish macules with telangiectasia on the upper arms, anterior chest, shoulders, and upper back. He had hypertension, diabetes, and hepatitis B infection for several years. Laboratory findings revealed ...

of unusual changes in the media. He gives an account of three necropsies of consecutive cases of rheumatic fever in young patients. The intima was not altered, but the media was thickened by increase of vascular elements, oedema and perivascular infiltration, with abundance of leucocytes and plasma cells. He noted signs of fibrous repair, and mentioned the possibility of this change predisposin...

Hand-foot-mouth (HFM) disease is primarily a disease of children, although it can be seen in immunocompromised adults. We describe a case of HFM disease in a 35-year-old immunocompetent male. He presented with multiple, 1~2 mm sized, erythematous vesicular papules on both hands and feet. Histopathological findings of a skin biopsy showed superficial perivascular lymphocytic infiltration, focal ...

Cutaneous small-vessel vasculitis (CSVV) is a general term for diseases that present pathological features of leukocytoclastic vasculitis, i.e., diseases with pathological perivascular neutrophilic infiltration and fibrinoid degeneration of the vascular walls (Fig. 11.1). Henoch-Schönlein purpura and urticarial vasculitis are included under a broad definition of CSVV; however, they are usually ...

BACKGROUND There are not many studies investigating histomorphological changes in 48 sessions in patients with early-stage MF after narrowband UVB (NBUVB) treatment. Our purpose is to evaluate histological features of phototherapy after 48 sessions and determine which parameters are more reliable for controlling skin biopsies. METHODS Biopsies of 32 patients with early stage of MF, who were t...

BACKGROUND Peculiar erythema known as annular erythema associated with Sjögren's syndrome (AESS) can be differentiated from autoimmune annular erythema and subacute cutaneous lupus erythematosus, both clinically and histologically. However, there are no detailed investigations on immune competent cells infiltration. OBJECTIVE Preferential infiltration of interleukin-17-producing T helper (Th1...