Objective: A significant percent of survivors from cardiac arrest and resuscitation suffer permanent brain damage. Previous studies have demonstrated the Neuroprotective effects of progesterone on regional brain ischemia and injury. In the present study, we investigate the Neuroprotective effects of progesterone on global brain ischemia as a result of cardiac arrest and resuscitation. Subjects:...

The fruit of Schisandra chinensis has been used in the traditional Chinese medicine for thousands of years. Accumulating evidence suggests that Schisandrin B (Sch B) has cardioprotection effect on myocardial ischemia in vitro. However, it is unclear whether Sch B has beneficial effects on continuous myocardial ischemia in vivo. The aim of the present study was to investigate whether Sch B could...

Cardiac magnetic resonance imaging (MRI) is increasingly used as the optimum modality for cardiac imaging. An aging population and rising numbers of patients with permanent pacemakers means many such individuals may require cardiac MRI scanning in the future. Whilst the presence of a permanent pacemaker is historically regarded as a contra-indication to MRI scanning, pacemaker systems have been...

Objective(s): Obestatin is a newly discovered peptide with antioxidant activities in different animal models. Recent studies have shown that Obestatin inhibits apoptosis following cardiac ischemia/reperfusion injury. Brain ischemia/reperfusion induces irreversible damage especially in the hippocampus area. This study aimed at examining the protective impact of Obestati...

Introduction: Reactive oxygen species (ROS) have been suggested to play an important role in the myocardial damage induced by ischemia – reperfusion. One element believed to be activated by ROS and to contribute to the reduction of ROS production, is the uncoupling protein-2 (UCP2). The objective of this investigation was to explore the effect of myocardial ischemia reperfusion on cardiac UC...

Aim: to study the effect of reperfusion on organized frequency-amplitude structure ventricular fibrillation (VF) in dog heart. Materials and methods. We conducted 4 experiments 8 dogs. In each experiment, isolated heart one was perfused with blood second (supporting) dog. an artificially heart, 6 episodes 3-minute ischemia 10-minute were performed VF (1-2 ischemia-reperfusion experiment). Each ...

BACKGROUND Chest pain is a hallmark of myocardial ischemia, but its underlying signaling mechanisms remain poorly understood. The capsaicin receptor, vanilloid receptor-1 (VR1), is an important cation channel present on primary nociceptive neurons. We have shown that the VR1 is expressed on sensory nerve endings of the heart. In the present study, we determined the role of VR1s in activation of...

background and objective: as one of the widely used drugs, aspirin (acetyl-salicylic acid, asa) plays an important role in stroke treatment and prevention. in a previous study, we demonstrated asa injection at 30 min after ischemia onset is neuroprotective. to determine whether the neurons protected by asa had a normal ultrastructure, hippocampal ca1 pyramidal neurons were examined by transmiss...

The development of ambulatory electrocardiographic recorders and analysers and the application of transesophageal echocardiography in the mid-1980's enabled investigators to quantify and describe the occurrence of silent as well as symptomatic ischemia in the perioperative period. Several technical advances which have recently occurred in ECG monitoring include the use of miniaturized digital c...

objective(s) the brief interruption of cerebral blood flow causes permanent brain damage and behavioral dysfunction. the hippocampus is highly vulnerable to ischemic insults, particularly the ca1 pyramidal cell layer. there is no effective pharmacological strategy for improving brain tissue damage induced by cerebral ischemia. previous studies reported that pentoxifylline (ptx) has a neuroprote...