A permeability prediction model for relaxed and sheared Non-Crimp Fabrics is proposed. The model is based on geometrical features of the fabric. The stitches penetrating the uni-directional plies of the NCF induce distortions of the fibres in the plane of the fabric. These Stitch Yarn induced fibre Distortions (SYD) form flow channels, which determine the permeability of the NCF. The channels a...

[1] Commonly, a soil’s relative permeability curve is predicted from its measured water retention curve by fitting equations that share parameters between the two curves (e.g., Brooks/Corey-Mualem and van Genuchten-Mualem). We present a new approach to predict relative permeability by direct application of measured soil water retention data without any fitting procedures. The new relative perme...

This study aimed to establish a practical and simplified method of predicting intestinal availability in humans (F(g,human)) at the drug discovery stage using in vitro metabolic clearance values and permeability clearance values. A prediction model for F(g,human) of 19 CYP3A substrates and 5 UGT substrates was constructed based on the concept that the permeability clearance values mean the perm...

PURPOSE The aim of the study was the prediction of human intestinal permeability and fraction absorbed of oral dose using single-pass intestinal perfusion technique (SPIP) in rats. METHODS Permeability coefficients in anaesthetized rats were determined for 14 compounds. Drug solution in phosphate buffered saline (PBS) was perfused through a ingle-pass intestinal perfusion (SPIP) with flow rat...

Severe influenza infections are featured by acute lung injury, a syndrome of increased pulmonary microvascular permeability. A growing number of evidences have shown that influenza A virus induces cytoskeletal rearrangement and permeability increase in endothelial cells. Although miRNA's involvement in the regulation of influenza virus infection and endothelial cell (EC) function has been well ...

BACKGROUND AND PURPOSE Increased blood-brain barrier permeability is believed to be associated with complications following acute ischemic stroke and with infarct expansion. Measurement of blood-brain barrier permeability requires a delayed image acquisition methodology, which prolongs examination time, increasing the likelihood of movement artefacts and radiation dose. Existing quantitative me...