Flower scent is an important trait of ornamental roses and has been character in the selection processes. In present study, composition volatile organic compounds (VOCs) emitted by both petals pollen 21 garden (Chinensis, Climber, English rose, Floribunda, Hybrid Tea, Multiflora, Damascena, Musk Polyantha, Rugosa Shrub) was investigated through GC-MS Static Headspace method. A total 19 differen...

OBJECTIVE Myasthenia gravis (MG) is an autoimmune condition in which neurotransmission is impaired by binding of autoantibodies to acetylcholine receptors (AChR) or, in a minority of patients, to muscle specific kinase (MuSK). There are differences in the dominant IgG subclass, pathogenic mechanisms, and treatment responses between the two MG subtypes (AChR or MuSK). The antibodies are thought ...

Myasthenia gravis (MG) is a B cell-mediated autoimmune disorder of neuromuscular transmission. Pathogenic autoantibodies to muscle-specific tyrosine kinase (MuSK) can be found in patients with MG who do not have detectable antibodies to the acetylcholine receptor (AChR). MuSK MG includes immunological and clinical features that are generally distinct from AChR MG, particularly regarding respons...

An important aspect of synapse development is the clustering of neurotransmitter receptors in the postsynaptic membrane. Although MuSK is required for acetylcholine receptor (AChR) clustering at the neuromuscular junction (NMJ), the underlying molecular mechanisms remain unclear. We report here that in muscle cells, MuSK interacts with Dishevelled (Dvl), a signaling molecule important for plana...

Agrin, a motoneuron-derived factor, and the muscle-specific receptor tyrosine kinase (MuSK) are essential for the acetylcholine receptor (AChR) clustering at the postjunctional membrane. However, the underlying signaling mechanisms remain poorly defined. We show that agrin stimulates a dynamic translocation of the AChR into lipid rafts-cholesterol and sphingolipid-rich microdomains in the plasm...

Synthetic musk fragrances are widely used as replacements for natural musks not only in perfumes but also in soaps, toiletries and disinfectants. The worldwide annual production of musk fragrances ranges between 6000 and 8000 metric tons per year, of which nitroand polycyclic musks represent 30 and 70%, respectively. As a result of their inherently low biodegradability, nitroand polycyclic musk...

We analyzed water samples from the confluence of three municipal sewage treatment effluent streams, surface water, and whole carp (Cyprinus carpio) for synthetic musks for a period of 7-12 months. The lipid content of each fish was determined and compared with the concentration of musks in the whole fish tissue. Enhanced methods were used for water sampling and musk extraction. The data present...

Musk odorants are used widely in cosmetic industries because of their fascinating animalic scent. However, how this aroma is perceived in the mammalian olfactory system remains a great mystery. Here, we show that muscone, one musk odor secreted by various animals from stink glands, activates a few glomeruli clustered in a neuroanatomically unique anteromedial olfactory bulb. The muscone-respons...

Agrin activates the transmembrane tyrosine kinase MuSK to mediate acetylcholine receptor (AChR) clustering at the neuromuscular junction (NMJ). However, the intracellular signaling mechanism downstream of MuSK is poorly characterized. This study provides evidence that geranylgeranyltransferase I (GGT) is an important signaling component in the Agrin/MuSK pathway. Agrin causes a rapid increase i...

In Multiple Instance Learning (MIL) problems, objects are represented by a set of feature vectors, in contrast to the standard pattern recognition problems, where objects are represented by a single feature vector. Numerous classifiers have been proposed to solve this type of MIL classification problem. Unfortunately only two datasets are standard in this field (MUSK-1 and MUSK-2), and all clas...