BACKGROUND Mild cognitive impairment (MCI) is considered to be a transitional stage between aging and Alzheimer disease (AD). OBJECTIVE To determine whether MCI represents early-stage AD by examining its natural history and neuropathologic basis. DESIGN A prospective clinical and psychometric study of community-living elderly volunteers, both nondemented and minimally cognitively impaired, ...

We used results from a national tuberculosis prevalence survey in Eritrea to calculate case detection rate (CDR) and compared it with the published CDR. The CDR obtained from the survey was approximately 40%, whereas the CDR published by the World Health Organization was 3x lower (14%).

This study evaluates rainfall estimates from the Next Generation Weather Radar (NEXRAD), operational rain gauges, Tropical Rainfall Measuring Mission (TRMM) Multisatellite Precipitation Analysis (TMPA), and Precipitation Estimation from Remotely Sensed Information using Artificial Neural Networks Cloud Classification System (PERSIANN-CCS) in the context as inputs to a calibrated, distributed hy...

Purpose. To investigate the agreement between morphometric optic nerve head parameters assessed with the confocal laser ophthalmoscope HRT III and the stereoscopic fundus camera Kowa nonmyd WX3D retrospectively. Methods. Morphometric optic nerve head parameters of 40 eyes of 40 patients with primary open angle glaucoma were analyzed regarding their vertical cup-to-disc-ratio (CDR). Vertical CDR...

abstract precipitation as the most important factor plays the main role in many application researches which are based on climatic parameters. many researches in the field of hydrology, hydrometeorology and agriculture employs rain-gauges (such as synoptic and climatologic stations) data. precipitation characteristics, such as rainfall intensity and duration, usually exhibit significant spatial...

The adenylate cyclase activity of a particulate preparation of rat cerebral cortex is comprised of two contributing components, only one of which requires a Ca’+-dependent regulator protein (CDR) for activity. The CDR-dependent component was stabilized by CDR. responded to increasing free Ca’+ concentrations biphasically (activation then inhibition), and was inhibited by high ratios of Mg’+ to ...

PG9 and PG16 are two recently isolated quaternary-specific human monoclonal antibodies that neutralize 70 to 80% of circulating HIV-1 isolates. The crystal structure of PG16 shows that it contains an exceptionally long CDR H3 that forms a unique stable subdomain that towers above the antibody surface to confer fine specificity. To determine whether this unique architecture of CDR H3 itself is s...

Background: Promoter hyper-methylation of tumor suppressor genes is a common event that occurs in cancer. As methylation is a reversible modification, agents capable of reversing an abnormal methylation status should help to combat cancer. 5-Aza-CdR is a DNA methyl-transferase inhibitor. The present study aimed to evaluate the effect of 5-Aza-CdR on the proliferation of human pancreatic cancer ...

The aim of this study was to explore the effects of 5-Aza-2'-deoxycytidine (5-Aza-CdR), a DNA methylation inhibitor, on the methylation state and function of the WWOX gene in the HO-8910 ovarian cancer cell line. The HO-8910 cells were divided into two groups, a control group and a 5-Aza-CdR-treated group. The methylation state of the WWOX gene was evaluated using a methylation-specific PCR ass...