نتایج جستجو برای: pestivirus infection
تعداد نتایج: 456359 فیلتر نتایج به سال:
Enveloped viruses have developed various adroit mechanisms to invade their host cells. This process requires one or more viral envelope glycoprotein to achieve cell attachment and membrane fusion. Members of the Flaviviridae such as flaviviruses possess only one envelope glycoprotein, E, whereas pestiviruses and hepacivirus encode two glycoproteins, E1 and E2. Although E2 is involved in cell at...
Classical swine fever (CSF) is a highly contagious and often fatal disease of swine caused by CSF virus (CSFV), a positive-sense single-stranded RNA virus within the Pestivirus genus of the Flaviviridae family. Here, we have identified conserved sequence elements observed in nucleotide-binding motifs (NBM) that hydrolyze NTPs within the CSFV non-structural (NS) protein NS4B. Expressed NS4B prot...
Small non-coding RNAs have emerged as key modulators of viral infection. However, with the exception of hepatitis C virus, which requires the liver-specific microRNA (miRNA)-122, the interactions of RNA viruses with host miRNAs remain poorly characterized. Here, we used crosslinking immunoprecipitation (CLIP) of the Argonaute (AGO) proteins to characterize strengths and specificities of miRNA i...
Temporal modulation of an autoprotease is crucial for replication and pathogenicity of an RNA virus.
Pestiviruses belong to the family Flaviviridae, and their genome is a single-stranded RNA of positive polarity encoding one large polyprotein which is further processed into mature proteins. Noncytopathogenic (noncp) strains of the pestivirus bovine viral diarrhea virus (BVDV) can establish persistent infection. In persistently infected animals, noncp BVDVs occasionally acquire mutations in vir...
The family Flaviviridae contains three genera of positive-strand RNA viruses, namely, Flavivirus, Hepacivirus (e.g., hepatitis C virus [HCV]), and Pestivirus. Pestiviruses, like bovine viral diarrhea virus (BVDV), bear a striking degree of similarity to HCV concerning polyprotein organization, processing, and function. Along this line, in both systems, release of nonstructural protein 3 (NS3) i...
Border disease (BD) is a viral disease of sheep and goats first reported in sheep in 1959 from the border region of England and Wales, and since recorded world-wide. Distribution of the virus is world-wide. Prevalence rates vary in sheep from 5% to 50% between countries and from region to region within countries. Clinical signs include barren ewes, abortions, stillbirths and the birth of small ...
This article reviews control options for Neospora caninum infection and abortion in cattle, drawing on published literature and the authors' own research in this field. Apart from the successful use of embryo transfer to prevent congenital infection in calves born to infected cows, there are currently no accepted control methods for the prevention of abortions in cattle. The epidemiological dat...
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