Chronic lymphocytic leukemia (CLL) represents one of the most active fields clinical research at present time.1, 2 This short review summarizes some basic, translational and that has led to substantial improvements management patients with CLL over past two decades. Biology: The use genetic genomic technologies an improved understanding biology CLL. Studies using fluorescent in-situ hybridizati...

introduction small and medium-sized enterprises (smes) bring a broad range of benefits beyond growth of national income, providing important opportunities for employment, and are a key source of an outlet for entrepreneurial creativity and ideas. however, it is estimated that smes are responsible around 60 percent of carbon dioxide emissions and 70 percent of all pollution globally. therefore, ...

•The investigation of immunotherapeutic agents for breast cancer has shifted from the metastatic to early setting.•Different scenarios and designs exist clinical trials testing immunotherapy in cancer.•Combinatorial strategies may increase activity across different subtypes.•Biomarkers predicting upfront resistance, treatment response, immune-related toxicities are needed.•Collaborative researc...

16 Exercise can effectively ameliorate type 2 diabetes and insulin resistance. Here we show that the 17 mRNA levels of one of peroxisome proliferator-activated receptor (PPAR) family members, 18 PPARγ1, and genes related to energy metabolism, including PPARγ coactivator-1 protein α 19 (PGC-1α) and lipoprotein lipase (LPL), increased in the gastrocnemius muscle of habitual 20 exercise-trained mi...

•A method for electrical-bias-dependent photoluminescence microscopy is introduced•The enables imaging of the local photocurrent in solar cells•Time-resolved charge-extraction demonstrated perovskite cells•Electrical coupling at interfaces and surface recombination revealed Spatial characterization methods are essential a deeper understanding physical phenomena quality control opto-electric dev...

170 words Narrative 3250 words Legends: 1870 words References: 54 Figures 8 all CMYK and to final size Editorial correspondence: David Kleinfeld Department of Physics 0374 University of California San Diego 9500 Gilman Drive La Jolla, CA 92093 Office: 858-822-0342 Mobile: 858-922-4664 Fax: 858-534-7697 Email: [email protected] Final draft: 2 January 2015 2 Abstract Whisking and sniffing are p...