The potential for convulsions induced by the coadministration of ciprofloxacin (CPFX) and foscarnet (PFA) may be due not to a change in the distribution of CPFX to the brain but to a potential CPFX-induced inhibition of gamma-aminobutyric acid (GABA)-GABA(A) receptor binding in the presence of PFA.

AIMS The aim of this study was to compare the effects of aspirin on platelet function as measured by the 'classical' template bleeding time with a new ex vivo method measuring closure times using the PFA-100 machine. Platelet aggregation in response to arachidonic acid was also measured ex vivo. METHODS The trial was a randomized, double-blind, placebo-controlled crossover design, with each v...

Diagnosis is the first analysis step for uncovering the root cause of failure for a defective chip. It is a fast and non-destructive approach to preliminarily identify and locate possible defects in a failing chip. Despite many advances in diagnosis techniques, it is often the case, however, that resolution, i.e., the number of locations or candidates reported by diagnosis, exceeds the number o...

A Particle Flow Algorithm (PFA) with the minimized dependence on the detector geometry is presented. Current PFA implementation includes procedures of the track reconstruction, calorimeter clustering, and individual particle reconstruction and is meant as a tool for the optimization of the International e + e − Linear Collider detector.

A rare case of true aneurysm of the profunda femoris artery (PFA) is reported. Surgical management consisted of ligation of the aneurysm and decompression of the sac. Presentation, diagnosis, and treatment of true PFA aneurysms are discussed and the English language literature is comprehensively reviewed.

In these notes and the accompanying lectures I introduce models of form PFA(S)[S], a useful class of models of set theory in which various consequences of both PFA and V = L hold. We list some of these consequences and topologically derive new results from them. Then we present some of the characteristic set-theoretic methods used to prove things in these models.

The class of parallel nite automata PFA is described that naturally expresses the interleaving parallelism inherent in Petri net notation without admitting the possibility of an in nite state space The equivalence of this class to deterministic nite automata DFA is demonstrated using an algorithm for generating an equivalent nondeterministic nite automaton NFA from a PFA A composition rule is g...

In patients with liver cirrhosis procoagulant and anticoagulant changes occur simultaneously. During primary hemostasis, platelets adhere to subendothelial structures, via von Willebrand factor (vWF). We aimed to investigate the influence of vWF on primary hemostasis in patients with liver cirrhosis. Therefore we assessed in-vitro bleeding time as marker of primary hemostasis in cirrhotic patie...

Plasmodium falciparum alanine M1-aminopeptidase (PfA-M1) is a validated target for anti-malarial drug development. Presence of significant similarity between PfA-M1 and human M1-aminopeptidases, particularly within regions of enzyme active site leads to problem of non-specificity and off-target binding for known aminopeptidase inhibitors. Molecular docking based in silico screening approach for...