Glycosyl halides are a very valuable and versatile group of synthetic intermediates widely used in carbohydrate chemistry for the ready functionalization at the anomeric carbon. Thus, glycosyl halides can be easily converted into O-glycosides, C-glycosides, or glycals via the generation of intermediate anomeric carbocations, radicals, or cabanions. Because of their moderate stability, glycosyl ...

C–H borylation of N-heteroarenes is an efficient yet highly challenging route to borylated aromatics. In a recent issue Nature, Leonori and co-workers demonstrated novel strategy toward this end by utilizing boryl-radical-based Minisci-type reaction that shows orthogonal site selectivity transition-metal-catalyzed approaches. Direct aromatic bonds straightforward means accessing diverse arene s...

The potent, naturally occurring immunomodulators (-)-rapamycin (1) and (-)-27-demethoxyrapamycin (2) have been synthesized via a unified and highly convergent strategy. In the preceding paper we discussed the construction of common building blocks A-C and their linkage to provide the C(21-42) segments of 1 and 2. Herein we describe model studies of triene generation and hydroxyl deprotection, t...

Fluorinated tungsten calix[4]arene imido complexes were synthesized and used as receptors to detect and differentiate neutral organic compounds. It was found that the binding of specific neutral organic molecules to the tungsten centers induces an upfield shift of the fluorine atom appended on the arylimido group, the extent of which is highly dependent on electronic and steric properties. We d...