Research on the biology of bacteriophages and their use in the treatment of bacterial infections Research into the isolation of phages specific to Stenotrophomonas maltophilia strains was continued utilizing 42 environmental samples. Seven specific bacteriophages which did not demonstrate lytic activity to other microorganisms of the Pseudomonadaceae family were isolated. Electonmicroscopic exa...

For a century, bacterial viruses called bacteriophages have been exploited as natural antibacterial agents. However, their medicinal potential has not yet been exploited due to readily available and effective antibiotics. After years of extensive use, both properly and improperly, antibiotic-resistant bacteria are becoming more prominent and represent a worldwide public health threat. Most impo...

Phage characterization for research and therapy can involve newly isolated phages propagated in pathogenic bacteria. If so, requires safety-managing the In current study, we adapt a common inexpensive reagent, PrimeStore (Longhorn Vaccines Diagnostics, San Antonio, TX, USA), to safety-manage bacteria 20 min by selectively inactivating No bacterial survivors are observed among >109 per ml rep...

introduction: epidermal growth factor receptor (egfr) has been shown to play a critical role in tumor cell growth and its overexpression has been observed in many epithelial tumors. in the field of cancer vaccine research, displaying the peptide mimotope on the surface of phage particles has shown promising results. methods: in this study using m13-pviii phage display system, two constructs wer...

The rapid rise of antibiotic resistance has renewed interest in phage therapy - the use of bacteria-specific viruses (phages) to treat bacterial infections. Even though phages are often pathogen-specific, little is known about the efficiency and eco-evolutionary outcomes of phage therapy in polymicrobial infections. We studied this experimentally by exposing both quorum-sensing (QS) signalling ...

Background: Antiviral screening of newly isolated or synthesized compounds is an important matter which requires a reliable antiviral test. In order to address this issue, the development of a rapid antiphage test has been conducted. To achieve this goal, the antiphage activity of three antiviral drugs (Acyclovir, Lamivudine and Trifluridin) against phage CP51 which infects Bacillus cereus (ATC...

Tumor blood vessels normalized by antiangiogenic therapy may provide improved delivery of chemotherapeutic agents during a window of time but it is unknown how protein expression in tumor vascular endothelial cells changes. We evaluated the distribution of RGD-4C phage, which binds alpha(v)beta(3), alpha(v)beta(5), and alpha(5)beta(1) integrins on tumor blood vessels before and after antiangiog...

Bacteriophages (phages) are viruses that specifically infect bacterial cells. Phages were first discovered in the early 1900s and soon after, the concept of phage therapy was conceived. Phage therapy involves the application of bacterial viruses to eliminate pathogenic bacteria. The results of early human trials were hampered by limited knowledge of phage biology, poor experimental design and i...

BACKGROUND The most serious criticisms leveled at bacteriophage therapy are as follows: phages induce neutralizing antibodies, phages are active only when administered shortly after bacterial infection, and phage-resistant bacteria emerge rapidly in the course of therapy. METHODS Phages lytic for several Salmonella enterica serovars were isolated by means of standard protocols from feces of p...