Polymeric micelles (PMs) are nanosized core-shell molecules formed by the self-assembly of amphiphilic block copolymers. Their unique morphologies, biocompatibility have allowed them to serve as drug carriers and found wide applications in pharmaceutical industry. This review summarizes recent progress PM development its field. Firstly, we discussed fundamentals polymeric micelles, formation me...

in this research at the first enalapril drug and its fullerene derivative were optimized. nbo calculations and nmr for the complexes were carried out at the b3lyp/6-31g* quantum chemistry level. different parameters such as energy levels, the amount of chemical shift in different atoms, the amount of homo/lumo, chemical potential (µ ), chemical hardness (η), the coefficients of hybrid bonds (π,...

background : staphylococcus aureus (s. aureus) is one of the major virulence factors of hospital and community acquired infections. healthcare workers can be the host of s.aureus for many months. and it is very important due to the possibility of transmission to patients. the aim of this study was to determine the prevalence of s.aureus nasal carriers, the antibiotic susceptibility pattern and ...

The sorption of poorly aqueous soluble active pharmaceutical ingredients (API) to mesoporous silica carriers is an increasingly common formulation strategy for dissolution rate enhancement this challenging group substances. However, the success approach a particular API depends on array factors including properties porous carrier, loading method, or attempted mass fraction API. At present, ther...

Lipases (3.1.1.3) are ubiquitous, biogenic enzymes which hydrolyses the triacylglycerols at water-oil interface. Many species of animals, plants, and microbes produces lipases. The organisms able to produce lipases could tolerate organic solvents, high temperature, is industrial interest. Apart from its natural aqueous catalysis it also performs synthetic reactions in non-aqueous conditions, ha...

Extracellular vesicles (EVs) are nanoparticles which released by cells from all three domains of life: Archaea, Bacteria and Eukarya. They can mediate cell-cell communication transferring cargoes such as proteins nucleic acids between cells. EVs receive great interest in both academia industry they have the potential to be natural drug carriers or vaccine candidates. However, limitations their ...

to create values in the working environment and to achieve the organizational aims, organizations have to manage their elements with specific alignment.in principle, different departments of organizations are put together with specific arrangements and tasks in order to create value for the stakeholders .it has been proven that creating value and the outcome of an organization has a direct rela...

Exosomes are a sub-group of extracellular vesicles, playing an important part in cell-cell communication many physiological and pathological conditions. Their size competence for transferring material to recipient cells make them promising nanocarrier clinical use. non-immunogenic nature, similar the body's own structure far superior transporters compared liposomes polymeric nanoparticles. This...