A highly efficient Ullmann homocoupling reaction of aryl halides using palladium (II) phosphine-ylide complexes as homogenous pre-catalysts under aerobic conditions has been developed without the need for any chemical co‐reducing agents. The procedure is relatively mild and appears to have broad applicability, being useful for the homocoupling of both electron-deficient and electron-rich aryl h...

In this study, the excellent scalability of flow chemistry was shown. Selective formation of mono-bromoketones was chosen as a model reaction. In a full multivariate optimization experiment, 60 different settings for reaction parameters such as temperature and reaction time were screened, requiring only small amounts of chemicals. A mathematical model of the data was obtained and an optimum set...

Iridium-catalyzed intramolecular [4 + 2] cycloadditions of diene-tethered alkynyl halides were investigated by using [IrCl(cod)](2) as catalyst, and dppe was found to be the most suitable phosphine ligand for the reaction. No oxidative insertion of the iridium into the carbon-halide bond was observed, and the reactions proceeded to provide the halogenated cycloadducts in good yield (75-94%). Th...

This account reviews transition metal-catalyzed C–C bond formation reactions using alkyl halides, which have rarely been used as carbon sources in conventional transition metal-catalyzed systems. In the reactions, ate complexes formed by the reaction of transition metals with a Grignard reagent play important roles as the active catalytic species. The reactions mentioned here are mechanisticall...

[reaction: see text] New air-stable PdCl(2){P(t)Bu(2)(p-R-Ph)}(2) (R = H, NMe(2), CF(3),) complexes represent simple, general, and efficient catalysts for the Suzuki-Miyaura cross-coupling reactions of aryl halides including five-membered heteroaryl halides and heteroatom-substituted six-membered heteroaryl chlorides with a diverse range of arylboronic acids. High product yields (89-99% isolate...

A highly efficient and selective synthesis of (1E)- or (1Z)-1,2-dihalo-1,4-dienes via Pd-catalyzed coupling of haloalkynes and allylic halides is described. The (1E)-1,2-dihalo-1,4-dienes were generated in good yields with excellent stereoselectivities (1E/1Z up to >98/2), while (1Z)-1,2-dihalo-1,4-dienes were produced in excellent yields and stereoselectivities (1Z/1E up to >98/2) by simply ad...

and 9b, were prepared as reported in the ref3). The other pivaloyloxymethyl esters, 9c, 9d and 9e, were prepared via another procedure, which is shown in Scheme 2. Other esters llp~ llw were prepared in the manner similar to that of 9e from the sodium salt of 5e and the corresponding halides. The latter halides were prepared from chloromethyl chlorosulfate (or chloromethyl iodide) and the corre-

The chromium-catalyzed enantioselective addition of carbo halides to carbonyl compounds is an important transformation in organic synthesis. However, the corresponding catalytic enantioselective arylation of ketones has not been reported to date. Herein, we report the first Cr-catalyzed enantioselective addition of aryl halides to both arylaliphatic and aliphatic ketones with high enantioselect...