SSUMMARY * A comparison of the respiration of Macaca mulatto restrained with strait jackets or injected intramuscularly with I mg 'kg of phencyclidine hydrochloride revealed that the minute volume of the strait-jacketed animals was about 3 times that of relatively unrestrained animals when measurements were made 10, 20, and 30 minutes after treatment. The values obtained from the drug-treated a...

4.1 Screening Strategy.................................................................................................................68 4.2 General Concepts ..................................................................................................................68 4.3 Basic Strategies .......................................................................................................

BACKGROUND Lack of discussion regarding actual asthma medication use by physicians with caregivers of children with asthma may result in low caregiver and physician concordance about prescribed asthma medications. OBJECTIVE The primary objective was to examine the concordance between primary care providers (PCP) and caregivers regarding child asthma medication use. METHODS Current asthma me...

The structural changes induced in the nicotinic acetylcholine receptor by two noncompetitive channel blockers, proadifen and phencyclidine, have been studied by infrared difference spectroscopy and using the conformationally sensitive photoreactive noncompetitive antagonist 3-(trifluoromethyl)-3-m-([(125)I]iodophenyl)diazirine. Simultaneous binding of proadifen to both the ion channel pore and ...

Introduction: Many studies have documented the deleterious effects of psychoactive substances like cocaine and amphetamines on the coronary vasculature. However, the impact of phencyclidine (PCP) on the arteries of the heart has largely gone unrecorded. Case Report: We report a case of a 41-year-old female presented to our hospital with chest heaviness, shortness of breath, and nausea, which st...

Cognitive deficits in various domains, including recognition memory, attention, impulsivity, working memory, and executive function, substantially affect functional outcomes in patients with schizophrenia. TAK-063 [1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one] is a potent and selective phosphodiesterase 10A inhibitor that produces antipsychoti...