نتایج جستجو برای: phenylthiocarbamide ptc

تعداد نتایج: 3669  

2006
Hendrik Decker Davide Martinenghi

An unconditional and hitherto unquestioned basic requirement for integrity checking is that the data need to be consistent before the update, such that the success of a simplified test can guarantee the invariance of integrity after the update. We answer the question whether this consistency requirement can be relaxed with ”Yes, at least sometimes, and to some extent.”

2013
Petra Helmond

Studies on the effectiveness of correctional treatment have widely failed to assess program integrity. This study examined the program integrity of EQUIP in 34 treatment groups of incarcerated offenders, using a new multiaspect program integrity instrument (MIPIE). The first aim of our study was to assess the reliability and validity of the MIPIE. The second aim was to describe the practical ap...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2012
Joanna Fombonne Pierre-Antoine Bissey Catherine Guix Rémy Sadoul Chantal Thibert Patrick Mehlen

Patched (Ptc), the main receptor for Sonic Hedgehog, is a tumor suppressor. Ptc has been shown to be a dependence receptor, and as such triggers apoptosis in the absence of its ligand. This apoptosis induction occurs through the recruitment by the Ptc intracellular domain of a caspase-activating complex, which includes the adaptor proteins DRAL and TUCAN, and the apical caspase-9. We show here ...

Journal: :Molecular cancer therapeutics 2010
Ying C Henderson Yunyun Chen Mitchell J Frederick Stephen Y Lai Gary L Clayman

Papillary thyroid carcinomas (PTC) are the most common type of thyroid malignancy. Most PTC carry one of the two mutations, RET/PTC rearrangement or BRAF mutation. Both mutations are able to activate the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (MEK/ERK) signaling transduction pathway leading to cellular proliferation, differentiation, and apoptosis. PD03259...

2016
Sirirat Anutrakulchai Tanin Titipungul Thanyaluk Pattay Putachart Mesung Anucha Puapairoj Dhavee Sirivongs Cholatip Pongsakul Prasit Futrakul Bandit Thinkhamrop Richard J. Johnson

BACKGROUND Experimental studies have linked peritubular capillary (PTC) loss with progression of chronic kidney disease. Minimal information on PTC in lupus nephritis (LN) has been reported. We therefore evaluated the PTC area in different classes of LN and determined if specific clinical characteristics correlated with PTC changes. METHODS Renal biopsies of 253 subjects with LN (categorized ...

2017
Liang He Siliang Zhang Xiaowen Zhang Rui Liu Haixia Guan Hao Zhang

Purpose This study was aimed to investigate the expressions of the insulin receptor (IR), insulin-like growth factor receptor (IGF-1R), and glucagon-like peptide-1 receptor (GLP-1R) in normal thyroid tissue, papillary thyroid cancer (PTC) tissues, and PTC cells, and to examine the possible role of insulin analogs and GLP-1R agonists in cell proliferation and energy metabolism in PTC cells. Me...

2016
Nurul-Syakima Ab Mutalib Sri Noraima Othman Azliana Mohamad Yusof Shahrun Niza Abdullah Suhaimi Rohaizak Muhammad Rahman Jamal

Background. Papillary thyroid carcinoma (PTC) is the commonest thyroid malignancy originating from the follicle cells in the thyroid. Despite a good overall prognosis, certain high-risk cases as in those with lymph node metastasis (LNM) have progressive disease and poorer prognosis. MicroRNAs are a class of non-protein-coding, 19-24 nucleotides single-stranded RNAs which regulate gene expressio...

Journal: :Mechanisms of Development 2000
Takashi Takabatake Tadashi C. Takahashi Yuka Takabatake Kazuto Yamada Masanori Ogawa Kazuhito Takeshima

Patched (Ptc) is a putative twelve transmembrane domain protein that is both a Hedgehog (Hh) receptor and transcriptional target of Hh. In this study, we isolated Xenopus Ptc cDNAs, Ptc-1 and Ptc-2, and carried out comparative analyses on their expression patterns. The putative Ptc-2 protein has a long C-terminal extension that has similarities in both length and sequence to those of Ptc-1 prot...

Journal: :European thyroid journal 2013
Eun Kyung Jang Dong Eun Song Gyungyub Gong Jung Hwan Baek Yun Mi Choi Min Ji Jeon Ji Min Han Won Gu Kim Tae Yong Kim Young Kee Shong Won Bae Kim

BACKGROUND It infrequently occurs that cytologic diagnosis of papillary thyroid carcinoma (PTC) cannot be confirmed by histology after surgery. This phenomenon may be a false-positive cytology or a true disappearing tumor. OBJECTIVES We evaluated patients who had consistent findings of PTC at fine needle aspiration cytology (FNAC) and no evidence of PTC in surgical specimens. METHODS Positi...

Journal: :International journal of clinical and experimental pathology 2015
Gang Wu Jing-Jing Guo Zhen-Yu Ma Jie Wang Zhong-Wen Zhou Yi Wang

The correlation between calcification and papillary thyroid carcinoma has received increasing attention. We investigated the ability of bone sialoprotein (BSP) and osteopontin (OPN) protein levels to diagnose papillary thyroid carcinoma (PTC), and explored the correlation between BSP and OPN protein levels and calcification in PTC. Archival PTC specimens from patients with PTC with calcificatio...

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