Despite the fact that only 21 fluorinated molecules are known to be biosynthesized, it is notable that about 20–25% of all modern pharmaceuticals and agrochemicals incorporate at least one fluorine atom. Nevertheless, the practice of introducing fluorine atoms into bioactive compounds is rather recent, as the first synthetic fluorinated drug, namely 5-fluorouracil, was synthesized as late as in...

Abstract Two-dimensional gas chromatography coupled to time-of-flight mass spectrometry (GC × GC-TOFMS) is a powerful tool for identification of compounds in complex samples. Herein, we compared the GC GC-TOFMS and systems polar metabolite profiling rice seeds. Forty-seven thirty-six metabolites were detected Korean cultivar, Dongjin, using GC-TOFMS, respectively. The limits detection shikimic,...

Plant metabolism is an important functional trait, and its metabolites have physiological ecological functions to adapt the growth environment. However, of from different provinces same plant species are still unclear. Therefore, this study aimed determine whether Masson pine ( Pinus massoniana Lamb.) corresponding metabolic traits. The gas chromatography–mass spectrometry technique metabonomic...

Microdroplets show unique chemistry, especially in their intrinsic redox properties, and to this we here add a case of simultaneous spontaneous oxidation reduction. We report the concurrent conversions several phosphonates phosphonic acids by reduction (R?P ? H?P) pentavalent phosphoric oxidation. The experimental results suggest that active reagent is water radical cation/anion pair. cation ob...

Abstract Herein, we present a novel approach for various asymmetric transformations of cyclic enones. The combination readily accessible chiral diamines and sterically demanding flexible phosphoric acids resulted in simple highly tunable catalyst framework. careful optimization the components led to identification particularly powerful multi‐purpose organocatalyst, which was successfully applie...