Sudden cardiac death (SCD) refers to death after an unexpected sudden cardiac arrest in a patient with or without known structural heart disease. The incidence of SCD in the United States ranges from 300 000 to 460 000 events per year, depending on the criteria for SCD used for surveillance. SCD results from a complex interaction between preexisting cardiac substrates, either structural or gene...

The free radical theory of aging postulates that the production of intracellular reactive oxygen species is the major determinant of life span. Numerous cell culture, invertebrate, and mammalian models exist that lend support to this half-century-old hypothesis. Here we review the evidence that both supports and conflicts with the free radical theory and examine the growing link between mitocho...

Mouse hindlimb ischemia has been widely used as a model to study peripheral artery disease. Genetic modulation of the enzymatic source of oxidants or components of the antioxidant system reveal that physiological levels of oxidants are essential to promote the process of arteriogenesis and angiogenesis after femoral artery occlusion, although mice with diabetes or atherosclerosis may have highe...

Bathorhodopsin-rhodopsin difference spectra of native 11-cis-rhodopsin and regenerated 9-cis-rhodopsin were measured at room temperature with a double-beam laser spectrophotometer after excitation at 532 nm. A detailed analysis of data obtained at 85 psec after excitation suggests that the bathorhodopsins generated from 11-cis- and 9-cis-rhodopsin differ in their extinction coefficients and tha...

Exposure of Escherichia coli to H2O2 leads to two kinetically distinguishable modes of killing: mode I killing occurs maximally near 2 mM H2O2, whereas mode II killing is essentially independent of H2O2 concentrations up to 20 mM. A major portion of H2O2 toxicity is attributed to DNA damage caused by the iron-mediated Fenton reaction. By studying DNA damage during Fenton reactions in vitro, the...

mesoporous tio2 has been prepared using a nonionic block copolymer (pluronic p-123) as structure-directing agent with sol-gel method. characterization of the product was carried out by means of x-ray diffraction (xrd), scanning electron microscopy (sem), thermogravimetry-differential scanning calorimetry (tg-dsc), nitrogen sorption isotherms, and uv-vis absorption spectroscopy. these analyses s...

In this paper, the photochemical degradation of azure-b by Cu2+/S2O82− process has beenpresented. Cu2+ as photocatalyst and S2O82− ion as photooxidant used in this process. Atextremely low concentrations, cupric ion showed true catalytic activity in the overall process.The influence of various parameters on the performance of the treatment process has beenconsidered, such as pH, concentration o...