PURPOSE. The most recently identified metabotropic glutamate receptor (mGluR), type 8 mGluR (mGluR8), has been identified functionally as a presynaptic autoreceptor in rod photoreceptors. This study analyzed the mechanism of action underlying mGluR8 activity and modulation of the cytosolic Ca concentration in mouse photoreceptors. METHODS. The cytosolic Ca concentration of acutely isolated rod ...
