Stimulus-responsive hydrogels have been widely used in the field of drug delivery because their three-dimensional pore size and ability to change release rate with external environment. In this paper, temperature-sensitive monomer 2-methyl-2-acrylate-2-(2-methoxyethoxy-ethyl) ethyl ester (MEO2MA) oligoethylene glycol methyl ether methacrylate (OEGMA) as well pH-sensitive N,N-Diethylaminoethyl (...

Photo-initiated polymer networks were formed by copolymerization of tert-butyl acrylate with di(ethylene glycol) dimethacrylate (DEGDMA) or poly(ethylene glycol) dimethacrylate (PEGDMA). The degree of crosslinking was systematically varied by modifying the weight fraction and molecular weight of the dimethacrylate crosslinking agent. An increase in effective crosslink density with increasing cr...

β-Nitroalcohols (βNAs) are promising corneoscleral crosslinking agents for the treatment of diseases such as keratoconus and myopia. Although it is believed that formaldehyde is released from the crosslinking reactions of βNAs, the mechanism by which βNAs react with amine-functionalized polymers has yet to be known. In this study, we present the reaction mechanism of the βNA crosslinking. Fouri...

Crosslinking and the resultant changes in mechanical properties have been shown to influence cellular activity within collagen biomaterials. With this in mind, we sought to determine the effects of crosslinking on both the compressive modulus of collagen-glycosaminoglycan scaffolds and the activity of osteoblasts seeded within them. Dehydrothermal, 1-ethyl-3-3-dimethyl aminopropyl carbodiimide ...

• Orange peel oil/HNT addition or crosslinking improved physical properties of films. Samples studied had distinctly different solubilities and visual appearances. oil HNT increased film hydrophobicity. All films other than control displayed antimicrobial activity. Biopolymer-based are natural, renewable, nontoxic biodegradable alternatives to plastic packaging. Despite years ongoing research, ...

Incubation in HeLa nuclear extract of a ^P-labeled 61 nucleotlde-tong RNA corresponding to the lariat branch site/polypyrlmldlne tract/3' splice site of the first Intron of human /S-globin pre-mRNA led to the crosslinking of a single protein of -62,000 mol. wt. (p62). p62 corresponds to a polypyrimidine tract-binding protein recently described by Garcia-Blanco et al. (Genes & Dev. 3: 1874-1886,...

Though silane chemistry has been used to crosslink unfilled polyethylene for many years, such crosslinking has only been recently applied to wood plastic composites to improve properties such as creep resistance. However, the presence of wood significantly changes the silane chemistry and a greater understanding is necessary for optimal processing and performance. We investigated three differen...

A novel crosslinking agent, suberoyl chloride, was used to crosslink N-phthaloyl acylated chitosan and improves the properties of chitosan membranes. Membranes with different crosslinking degrees were synthesized. The derivatives were characterized by Fourier transform infrared spectroscopy and ¹³C solid state nuclear magnetic resonance spectroscopy, which indicated that the crosslinking degree...

In this study, a chitosan substrate was modified by simulated body fluid (SBF) treatment, in which the effect of the chosen crosslinking agent was investigated. Two crosslinking agents, glutaraldehyde (GA) and sodium tripolyphosphate (TPP), were used before the SBF process. By using TPP as the crosslinking agent, the Ca/P ratio and the degree of crystallinity were very close to the natural bone...