BACKGROUND Mutations in LYST, a gene encoding a putative lysosomal trafficking protein, cause Chédiak-Higashi syndrome (CHS), an autosomal recessive disorder typically characterized by infantile-onset hemophagocytic syndrome and immunodeficiency, and oculocutaneous albinism. A small number of reports of rare, attenuated forms of CHS exist, with affected individuals exhibiting progressive neurod...

Chlorpromazine is known to cause ocular pigmentary deposits. However, delayed presentation after cessation of chlorpromazine has not been reported. There are also no reports on whether newer generation of anti-psychotic agents contribute to ocular toxicity. We describe a case of ocular toxicity related to anti-psychotic agents. To the best of our knowledge, this is the first reported case of an...

Primary pigment dispersion syndrome (PPDS) is a bilateral condition that occurs in anatomically predisposed individuals. PPDS may evolve into pigmentary glaucoma, but it is difficult to predict which patients will progress. Secondary pigment dispersion is more often unilateral and acquired as a result of surgery, trauma, or intraocular tumor, but can likewise lead to pigmentary glaucoma. We rep...

BACKGROUND Erythema dyschromicum perstans (EDP)/Ashy dermatosis (AD), Lichen planus pigmentosus (LPP) and Pigmented contact dermatitis (PCD) are common skin diseases featuring abnormal pigmentation which have overlapping clinical features. OBJECTIVE To search for differences in the natural history, clinical features, histopathology and relevant contact allergens in patients those were clinica...

    Pityriasis Alba is an eruptive skin disorder which occurs as dry hypopigmented , scaly patches appears mainly in sun expose areas of skin, usually in children and young adolescents. Complete cure occurs within few years even without treatment. Few trace elements play essential roles as cofactors in pigmentary process of the skin. In this study by determination of zinc and copper levels in...

We present a new analysis of parton distributions of the proton. This incorporates a wide range of new data and an improved treatment of heavy flavours and prompt photon production. The new set (MRST) shows systematic differences from previous sets of partons which can be identified with particular features of the new data and with improvements in the analysis. We also investigate the sensitivi...

The genetic and molecular bases of various types of congenital pigmentary disorders have been classified in the past 10 years, as follows: (1) disorders of melanoblast migration in the embryo from the neural crest to the skin: piebaldism; Waardenburg syndrome 1-4 (WS1-WS4); dyschromatosis symmetrica hereditaria. (2) Disorders of melanosome formation in the melanocyte: Hermansky-Pudlak syndrome ...

History.?In October 1910, the patient, Sepoy T. K., 27th Punjabis, showed me some pigmented spots on iiis face, hands and left leg. They first appeared in March, 1U0S, when the patient was living in Jhandola. He believed that quinine, which he was taking prophylactically at that time, caused their appearance. No fresh spots have appeared since then, but some of the original areas have increased...