Skin pigmentary disorders and uneven skin tone represent common cosmetic concerns in Japan where fairer skin is culturally desirable. As the demographics of Asian countries continue to evolve, there is a need to understand the impact of cosmetic skin concerns on quality of life (QoL). 199 Japanese women self-claiming facial skin pigmentation disorders were asked to complete the BeautyQoL questi...

BACKGROUND To assess the effect of smoking on lip and gingival pigmentation and also to assess the relationship of pigmentation with periodontal parameters. MATERIALS AND METHODS 109 smokers and an equal number of control subjects who were nonsmokers in the age range of 35 - 44 years comprised the study sample. All the participants were assessed for pigmentation on lip and gingiva and a total...

Abnormal pigmentation is related to a variety of cosmetic and clinical conditions including melasma, lentigo, age spots, vitiligo, etc. Numerous actives designed to modulate skin tone have been utilized as cosmetics and pharmaceuticals to address these conditions. We report on an optimized short-term (1-week) protocol using the Asian MelanoDermTM model (MatTek Corporation) and designed to rapid...

Waardenburg syndromes are characterized by pigmentation and autosensory hearing defects, and mutations in genes encoding transcription factors that control neural crest specification and differentiation are often associated with Waardenburg and related disorders. For example, mutations in SOX10 result in a severe form of Waardenburg syndrome, Type IV, also known as Waardenburg-Hirschsprung dise...

Ectodermal dysplasias (EDs) are a large heterogeneous group of inherited disorders exhibiting abnormalities in ectodermally derived appendages such as hair, nails, teeth and sweat glands. EDs associated with reticulated pigmentation phenotype are rare entities for which the genetic basis and pathophysiology are not well characterized. The present study describes a five generation consanguineous...

how to cite this article: mansouri nejad se, yazdan panah mj, tayyebi meibodi n, ashrafzadeh f, akhondian j, beiraghi toosi m, eslamieh h. griscelli syndrome: a case report. iran j child neurol. 2014 autumn;8(4): 72-75. objective griscelli syndrome (gs) is a rare autosomal recessive immune deficiency disorder that presents with pigmentary dilution of the skin and hair, recurrent skin and pulmon...

Since its use was first reported by 8rowne and Hogerzeil in 1962 ('0. /I), 8663, a synthesized phenazine dye, has proven to be an effective drug in the treatment of human leprosy and its use has become worldwide ( 2.7.9 " . 26. 3~. 39. 52. 5.1 ). The most significant and frequent side effect of this compound is an abnormal skin coloration. This can be divided into two types. One is an initial r...

Endothelin-1 (ET-1) plays an indispensable role in epidermal pigmentation in hyperpigmentary disorders due to a central role in melanogenesis. Nevertheless, precise mechanism involved in ET-1-induced hyperpigmentation is still undefined. Glycoprotein (transmembrane) non-metastatic melanoma protein b (GPNMB) is a key element in melanosome formation. Therefore, we speculated that GPNMB was correl...

A research study was carried out on the indirect selection efforts amongst small scale holders of West African Dwarf (WAD) goats based on coat pigmentation and wattle types in Ogbomoso, Nigeria using personal interviews and structured questionnaires given using simple random on-farm techniques. The questionnaires were focused on the ownership distribution, preferred pigmentation and wattle type...

Multiple café-au-lait macules (CALM) are usually associated with neurofibromatosis type 1 (NF1), one of the most common hereditary disorders. However, a group of genetic disorders presenting with CALM have mutations that are involved in human skin pigmentation regulation signaling pathways, including KIT ligand/KIT proto‑oncogene receptor tyrosine kinase and Ras/mitogen‑activated protein kinase...