In the title compound, C(23)H(26)ClNO(4), the piperidine ring adopts a distorted boat conformation. The two methoxy-phenyl groups at the 2 and 6 positions of the piperidine ring are in axial and equatorial orientations. An intra-molecular C-H⋯Cl inter-action is observed. In the crystal, the mol-ecules are linked into zigzag chains along the b axis by C-H⋯π inter-molecular inter-actions.

Ix the course of a research undertaken for another purpose I had occasion to compare the actions of several compounds of piperidine, and, as my results differ somewhat from those of other workers in this field, I have thought it wcll to publish them now, as I see no prospect oi prosecuting the subject further. The substances examined were piperidine~ a-methylpiperidine, a-ethylpiperidine~ and c...

In order to discover novel eco-friendly lead compounds for plant pathogenic fungi control, a series of benzaldehyde thiosemicarbazide derivatives with a piperidine moiety have been designed and synthesized. Fungicidal activities of all the synthesized compounds were evaluated in vitro. The results indicated that all the title compounds exhibited moderate to good fungicidal activities. Compound ...

When meperidine (Demerol) was shown to possess marked analgesic properties (Eisleb and Schaumann, 1939) and thus became the first potent synthetic analgesic drug, the importance of the 1,4-substituted piperidine nucleus in providing analgesic activity became apparent. Many modifications of this basic chemical structure have been synthesized and studied pharmacologically in an attempt to achieve...

A series of piperidine-based derivatives were identified as novel and potent inhibitors of the influenza virus through structural modification of a compound that was selected from a high-throughput screen. Various analogues were synthesized and confirmed as inhibitors. The structure–activity relationship (SAR) studies suggested that the ether linkage between the quinoline and piperidine is crit...

A new series of novel heterocyclic compounds containing both tetrazoles and piperidine nuclei together, namely, 1-(1-aryl-1H-tetrazol-5-yl)-2-(piperidin-1-yl)ethanone (22-28), were synthesized by the treatment of the respective 2-chloro-1-(1-aryl-1H-tetrazol-5-yl)ethanone (15-21) with piperidine in acetonitrile for 6 h. A series of novel tetrazole substituted piperidine derivatives were synthes...

The use of synthetic insecticides in agriculture over the years has resulted in the development of resistance in insect pest populations and environmental problems. Therefore, it is highly desirable to develop new selective insecticidal agents based on natural products. Piperidine alkaloids occur widely in plants as well as in the animal kingdom. Due to their great diversity in biological and p...

This paper presents a novel unified theory of the structure activity relationship of opioids and opioid peptides. It is hypothesized that a virtual or known heterocyclic ring exists in all opioids which have activity in humans, and this ring occupies relative to the aromatic ring of the drug, approximately the same plane in space as the piperidine ring of morphine. Since the rings of morphine a...

In the title salt, C6H14N3(+)·C3H5O3(-), the C-N bond lengths in the central CN3 unit of the carboxamidinium cation are 1.3262 (18), 1.3359 (18) and 1.3498 (18) Å, indicating partial double-bond character. The central C atom is bonded to the three N atoms in a nearly ideal trigonal-planar geometry and the positive charge is delocalized in the CN3 plane. The piperidine ring is in a chair conform...

Background and Objective: Regarding the prevalence of epilepsy in human society and with respect to insufficiency of usual treatments, new strategies and methods for medical treatment of epileptic patients are necessary. As NMDA receptor antagonists are the most prominent anti-epileptic drugs, in the present study, we synthesized and investigated anti-epileptic effect of a new piperidine deriva...