wide interest because the 1H-pyridin-2-ones obtained in this process are versatile synthetic building blocks in the synthesis of alkaloids,1–5 although little has been done concerning their use in asymmetric synthesis. This contrasts with the large use of chiral piperidones, which have recently been reported. The synthetic method proceeds first through the addition of the hydroxide anion at pos...

A diagnosis of advanced ovarian cancer is the beginning of a long and arduous journey for a patient. Worldwide, approximately half of the individuals undergoing therapy for advanced cancer will succumb to the disease, or consequences of treatment. Well-known and widely-used chemotherapeutic agents such as cisplatin, paclitaxel, 5-fluorouracil, and doxorubicin are toxic to both cancer and non-ca...

The present study was designed to synthesize isomeric alcohols from corresponding piperidone 1 by sodium ethoxide reduction and the alcohols were separated by column chromatography. The synthesized compounds were characterized by IR, 1H & 13C spectral studies. In addition to that in vitro potential antioxidant activity of the compounds were analyzed via DPPH assay and compared with standard ant...