AIM Large plaque burden, expansive vascular remodelling, and spotty calcification have been considered as important morphologies of high-risk plaques causing acute coronary events. Although non-occlusive rupture of high-risk plaques has been proposed as a mechanism for disease progression in post-mortem studies, the natural history of coronary atherosclerosis in stable patients with high-risk p...

PURPOSE T1-weighted (T1W) magnetic resonance images with magnetization transfer (MT) are widely used in the evaluation of multiple sclerosis (MS) plaques. We aimed to evaluate the contribution of the subtraction technique with MT in the detection of acute MS plaques. MATERIALS AND METHODS Sixty-four patients during an MS attack were enrolled in the study. Axial T1W spin echo (SE) with MT, axi...

OBJECTIVE To investigate the hypothesis that COMP can influence the morphology, stability and size of murine atherosclerotic lesions. METHODS ApoE- and ApoE/COMP-knockout mice were fed a high-fat diet to develop atherosclerotic plaques at lesion sites of three different types; inflammatory and fibrous plaques induced in the carotid artery by low or oscillatory shear stress, respectively, and ...

accretion de nouvelle croute oceanique en afar, en domaine subaerien' est precisee par diverses methodes d'investigations geologiques et geophysiques. les donnees recueilles permettent d'identifier en afar des structures equivalentes aux vallees axiales, aux failles transformantes et aux zones de fracture. les donnees permettent d'interpreter la plupart des observations geol...

Scalp involvement with hair loss is common in systemic lupus erythematosus. Discoid erythematosus may cause scarring alopecia, characterized by well-delimited erythematous plaques scales, follicular hyperkeratosis and atrophy, which considered a trichological emergency. Early diagnosis treatment are necessary order to prevent permanent loss. We describe 44 years’ old female patient for 4 years,...

OBJECTIVES Low-density lipoprotein (LDL) is an important risk factor for coronary artery disease. However, its localization in human coronary plaques is not well understood. The present study was performed to visualize LDL in human coronary artery wall. METHODS (1) The fluorescence characteristic of LDL was investigated by color fluorescent microscopy (CFM) with excitation at 470-nm and emiss...

We report here routine thin-section and immunogold electron microscopic studies on diffuse plaques in scrapie-affected hamster brains. These plaques were not discernible by routine HE staining. Ultrastructurally, plaques were recognized as areas of low electron density containing haphazardly-oriented fibrils, but not as stellate compact structures typical of mouse scrapie models; hence we label...

In this paper, a new type of spot desmosome-like junction (type II plaque) is described that is scattered along the entire lateral plasma membrane of rat and human intestinal epithelium. Ultrastructurally type II plaques differed from the classical type of epithelial spot desmosome ("macula adherens", further denoted as type I desmosome) by weak electron density of the membrane-associated plaqu...

BACKGROUND It is generally well-known that smoking has a substantial impact on general health, and cardiovascular health in particular. The purpose of this study was to analyze the effects of different smoking status on the burden and characteristics of coronary artery plaques in Chinese men. METHODS Our study enrolled 1920 individuals with suspected coronary artery disease undergoing 256-det...

Multidetector computed tomography (MDCT) provides 3-dimensional noninvasive visualization of the coronary arterial tree. We compared MDCT with intravascular ultrasound (IVUS) for assessment of severity of coronary artery stenosis and composition of atherosclerotic plaques in 40 patients (32 men; mean age 52 years, range 33 to 86) with documented coronary artery disease. Cross-sectional images o...