With advances in basic science, the use of biological adjuncts is currently being explored to supplement orthopedic surgery. Platelet-rich plasma is a clinical concept of autologous intraoperative concentration of serum platelets to provide high levels of early critical growth factors for implantation into fracture, arthrodesis, or nonunion sites. The theoretical benefit of a biological adjunct...

A series of indole-based aryl(aroyl)hydrazone analogs of antiplatelet indole-3-carboxaldehyde phenylhydrazone were synthesized by the Schiff base formation reaction and their antiplatelet activity was assessed using human platelet rich plasma. The platelet concentrate was obtained using a two-step centrifugation protocol and ADP, arachidonic acid and collagen were used as inducers of platelet a...

<p>Transfusi trombosit sebagai terapi utama bagi pasien dengan trombositopenia. Pasien dewasa, sekitar 6 unit TC-PRP dibutuhkan dosis tersebut setara 1 <em>platelet apheresis</em>. Semakin banyak yang ditransfusikan maka akan semakin tinggi paparan residu leukosit diterima<em>.</em> Penelitian ini mengetahui perbandingan kualitas dan apheresis </em>dilihat da...

Purpose Herein we evaluated the effects of platelet concentrate (PC) and platelet-poor plasma (PPP) on bone repair using noncritical defects in calvaria rabbits compared them to presence TGF-β1 osteocalcin reparative sites. Methods Five 8.7 mm diameter were created 15 animals. Each defect was treated differently, autograft (ABG), ABG associated with PC (ABG + PC), PPP PPP), isolated PPP, blood ...

Introduction. Oroantral communication (OAC) closure may be accompanied with hard and soft tissue defects. Platelet-rich fibrin (PRF) is the second-generation platelet concentrate that can an effective therapeutic option for of defects up to 5mm. The aim this investigation was evaluate whether PRF could a viable OAC provide sufficient bone quality/quantity forthcoming implant placement. Outlines...

BACKGROUND Platelet transfusion therapy poses many challenges in veterinary clinical practice. Lack of readily available blood donors, short shelf-life, and inability to administer a sufficient number of platelets to meet a dog's transfusion need are the major difficulties encountered. Platelet additive solutions are already in use at American and European human blood banks, showing to be a rea...

OBJECTIVE Thoracoabdominal aortic aneurysm operations are associated with extensive blood loss and high requirements for allogeneic blood product transfusion. We assessed the efficacy of intraoperative post-cardiopulmonary bypass administration of fibrinogen concentrate in elective thoracoabdominal aortic aneurysm surgery. METHODS In a retrospective group (group A, n = 12) of patients undergo...

BACKGROUND The study of platelet aggregation is essential to assess in vitro platelet function by different platelet activation pathways. OBJECTIVE To assess aggregation and biochemical parameters of random platelet concentrates produced at the Fundação HEMOAM using the quality control tests defined by law. METHODS Whole blood samples from 80 donors and the respective platelet concentrate u...