The development of neuroprotective strategies to attenuate retinal ganglion cell death could lead to novel therapies for chronic optic neuropathies such as glaucoma. Intravitreal transplantation of mesenchymal stem cells slows retinal ganglion cell death in models of optic nerve injury, but the mechanism of action remains unclear. Here we characterized the neuroprotective effects of mesenchymal...

Action mechanisms underlying various biological activities of collagen peptides (CPs) remained to be elucidated. Cytokines may play an important role in mediating these health benefits of CPs. This study aimed to systemically examine the cytokines in skin and blood regulated by CPs intake. Thirteen-month-old female Kunming mice were administered with CPs for 2 months (0 or 400 mg/kg bodyweight/...

background and objective: vascular endothelial growth factor (vegf) and its receptors (vegf-r1 and r2) are major regulators of angiogenesis. this study was designed to assess serum levels of vegf and vegf-r1 and their prognostic significance in newly diagnosed childhood acute leukemia. materials and methods: for this purpose, vegf and vegf-r1 were determined using enzyme linked immuno-sorbant a...

INTRODUCTION: Platelet-rich plasma (PRP) belongs to one plasma division isolated by centrifugation of whole blood. From 1981 to 1991, a number of different growth factors containing platelets were reported one after another, such as platelet-derived growth factor (PDGF), transforming growth factor beta 1 (TGF-b1), transforming growth factor beta 2 (TGFb2), insulin-like growth factor (IGF), epid...

Citation: Sevinç B. Platelet Rich Plasma Application to Prevent Wound Complications. J Univer Surg. 2016, 4:4. Recently, there are numerous medical treatment options for disorders we used to operate before. Platelet rich plasma (PRP) is nowadays routinely used in medicine especially in orthopaedics and for cosmetic purposes. PRP with high rates of platelets and growth factors included in accele...

Autologous platelet-rich plasma (PRP) may enhance wound healing through the formation of a platelet plug that provides both hemostasis and the secretion of biologically active proteins, including growth factors such as platelet-derived growth factor, transforming growth factor (TGF)-β, TGF-β2, and epidermal growth factor. The release of these growth factors into the wound may create an environm...