The processing of whole blood-derived platelet-rich plasma (PRP) to a platelet concentrate and platelet-poor plasma is currently performed within 8 hours to comply with the requirements to manufacture fresh frozen plasma. Maintaining PRP at room temperature for a longer period can have the advantage of shifting the completion of component manufacture onto day shifts. Pairs of ABO-identical prep...

Flow cytometric detection of platelet surface-associated IgG (PSAIgG) can be used to determine whether immunologic factors are contributing to thrombocytopenia in dogs. In vitro alterations in platelet activation and morphology, however, could impact the results of this test. The purpose of this study was to determine whether the PSAIgG test for immune-mediated thrombocytopenia was valid on who...

  I read with interest Dr. Yazdani's reply about the article entitled “administration of magnesium sulfate to women with premature labor: The effect on bleeding time”.1 In my review of hematology references, I could not find any reference for determining hemoglobin (Hb) sooner than 24 hrs and Dr. Yazdani had not cited any reference either. However, about the influence of Hb on homeostasis, ther...

Platelet concentrates (PCs) are widely used in transfusion medicine for therapeutic purposes and their demand is constantly on the rise. Current storage regulations make this product highly susceptible to bacterial contaminations platelet lesions (PSL) causing need alternative methods be considered. The implementation of cold not only reduces unnecessary wastage valuable donations overall costs...

The mean platelet component (MPC) parameter calculated by the ADVIA blood cell analyzers provides direct information on density, or granularity, of platelets and could become a useful biomarker to detect in vivo platelet activation. Unfortunately, it is largely affected by time and storage conditions in standard anticoagulants based on EDTA. The present study was designed to improve the stabili...

Platelet transfusion therapy has played an important role in the management of patients [4]. Today, a variety of methods for the preparation of platelets for transfusion are available ,which may be due to different processing systems such as apheresis ,buffy coat and platelet rich plasma platelet concentres methods [5,6]. Processing and storage may affect both platelet quality and function and ...