نتایج جستجو برای: platelet von willebrand factor
تعداد نتایج: 1021349 فیلتر نتایج به سال:
In this issue of Blood, Brill and colleagues demonstrate that von Willebrand factor (VWF) release and subsequent platelet adhesion to endothelial cells are required for thrombus formation in a mouse model of deep venous thrombosis (DVT).
A 10-year-old male patient affected by type 2 von Willebrand disease (vWD) and his family members were investigated by hemostatic and molecular genetic studies. The propositus, who experienced frequent bleeding episodes, was characterized by a normal level of von Willebrand factor (vWF) antigen (54%), reduced vWF ristocetin cofactor activity (5%), decreased factor VIII clotting activity (25%) a...
Introduction: The estіmated number of people with diabetes worldwide in 2015 is 415 million persons, up to 91% of adults hadtype 2 diabetes and the crude incidence of stroke among patients with diabetes of the 2type can be more than 3 times that in the general population. It is known platelet activation and aggregation are critical in the pathogenesis of acute ischemic cerebrovascular diseases....
Factor VIII functions as a cofactor in the intrinsic coagulation pathway and must first be activated to function optimally in this capacity. Low concentrations of thrombin activate factor VIII, and the presence of stimulated platelets is known to enhance the activation of factor VIII complexed to von Willebrand factor. The current studies show that platelets stimulated by thrombin, collagen, or...
Thrombosis, especially arterial, develops by mediation of platelets, adhering to collagen fibers at areas of endothelial cell damage. At this phase, platelet activation leads them to secrete factors [ADP, Fibrinogen, von Willebrand Factor (vWF), Fibronectin, Factor XIII] capable of promoting cell aggregation/adhesion and coagulation, inducing vasoconstriction (thromboxane A2) and acting as mito...
Background: Bernard-Soulier syndrome is a rare inherited bleeding disease caused by quantitative or qualitative defect of GPIb/IX/V, a platelet complex that binds the Von Willebrand factor. The expression of GPIb-IX-V complex can be evaluated by flow cytometry and confirmed by the absence of ristocetin-induced platelet aggregation in platelet-rich plasma. The main aim of the present study was t...
Looking back at the last thirty years of studies on von Willebrand factor is a lesson on the importance of combining clinical observations with basic research. Most of what we know today originates from the perceptive evaluation of patients with congenital disorders of haemostasis such as haemophilia and von Willebrand disease. Understanding the causes of these diseases was akin to the current ...
The relationships between the Platelet Function Analyzer (PFA)-100 and von Willebrand factor (VWF) levels and bleeding score (BS) were evaluated within a multicentre project on Molecular and Clinical Markers for the Diagnosis and Management of type 1 von Willebrand disease (MCMDM-1VWD). PFA-100 closure time, either with epinephrine (EPI) or adenosine diphosphate (ADP)-cartridges, was measured i...
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