A topological index is a molecular descriptor derived from the structure of chemical substance. These indices can be used to analyze mathematical values and predict various physical properties drugs. This article discusses tofacitinib, leflunomide, upadacinib, baricitinib, filgotinib, methotrexate, other drugs treat rheumatoid arthritis, goal QSPR study calculate relationship between under inve...

The authors exploit the remarkable similarity between recent climate trends and the structure of the ‘‘annular modes’’ in the month-to-month variability (as described in a companion paper) to partition the trends into components linearly congruent with and linearly independent of the annular modes. The index of the Northern Hemisphere (NH) annular mode, referred to as the Arctic Oscillation (AO...

The influence of the Indian Ocean Dipole (IOD) on the interannual atmospheric pressure variability of the Indo-Pacific sector is investigated. Statistical correlation between the IOD index and the global sea level pressure anomalies demonstrates that loadings of opposite polarity occupy the western and the eastern parts of the Indian Ocean. The area of positive correlation coefficient in the ea...

Of the placebo-controlled maintenance studies conducted in bipolar disorder, few have enrolled patients who present depressed. In fact, only lithium and lamotrigine have been studied over the long term with placebo-controlled designs in recently manic and recently depressed bipolar patients. Given the magnitude of the unmet medical need and the data suggesting that symptomatic patients with bip...

BACKGROUND Predominant polarity characterises patients who mainly manifest recurrences of depression or mania/hypomania. Alcohol use disorder (AUD) and polysubstance use (PSU), which often complicate bipolar disorder (BD) and affect its clinical course, can influence predominant polarity. Nevertheless, previous studies have not clarified if BD patients differ in predominant polarity from BD pat...

We perform ab initio density functional calculations to study the flow of water, methanol, and dimethyl ether through nanotubes carbon boron nitride with different diameters chiralities. The liquids we choose are important solvents, water methanol being polar nonpolar. In terms activation barriers for liquid transport, find molecular-level drag decrease decreasing nanotube diameter but be rathe...