[μ-(linker)L2(dipyrido[3,2-a:21,31-c]phenazine)2(phenanthroline)2Ru(II)2]2+ with linker: 1,3-bis-(4-pyridyl)-propane, L: PF6 (bis-Ru-bpp) was synthesized and their binding properties to a various polynucleotides were investigated by spectroscopy, including normal absorption, circular dichroism(CD), linear dichroism(LD), and luminescence techniques in this study. On binding to polynucleotides, t...

A novel N-sulfonyl aziridine, N-((2-(trimethylsilyl)ethyl)sulfonyl)-2-methyl-aziridine (SES-MeAz) was synthesized, and its controlled anionic ring-opening polymerization to form poly(SES-MeAz) studied. The desulfonylation of poly(SES-MeAz)s can be achieved under mild conditions, with tetrabutylammonium fluoride (TBAF) polypropylene imine (PPI), although purification the PPI not completely succe...

Mouse bladder tumor (MBT-2), derived from a carcinogen-induced transitional cell carcinoma of the bladder, has proven a useful model for study of pathogenesis and prediction of cytotoxic drug sensitivity of human bladder carcinoma. To define optimal conditions for activity of the potent interferon inducer polyriboinosinic-polyribocytidylic acid [poly(I) X poly(C)] in this model, studies of dose...

Sonogashira coupling of 9,9-bis(2-ethylhexyI)2,7-diethynyl-9H-fluorene (I) with 2,7-dibromo-9,9-bis(2ethylhexyl)-9H-fluorene (2) and dibromo-substituted electron accepting arylenes 5,7-bis(5-bromothiophen-2-yl)-2,3dihexylthieno[3,4-b)pyrazine (3), 4,7-bis(5-bromo-4-(2ethylhexyl)thiophene-2-yI)bis(benzothiadiazole) (4) or 4,9bis (5-bromo-4-{2-ethylhexyl)thiophen-2-yl)-6, 7dihexylthiadiazolo(3,4-...

A human monoclonal macroglobulin IgM"°", has recently been described which has specificity for poly-a(2-"8)-linked N-acetylneuraminic acid (NeuNAc), 1 the specific capsular polysaccharide of the group B meningococcus and of Escherichia coli Kl (1) . Although studies using this polysaccharide as a vaccine in humans have been unsuccessful (2-4, see reference 5), the serum contained over 20 mg of ...