Nowadays, 2-ethylhexyl 4-(N,N-dimethylamino)benzoate (EDP) is one of the most widely used UV filters in sunscreen cosmetics and other cosmetic products. However, undesirable processes such as percutaneous absorption and biological activity have been attributed to this compound. The in vitro metabolism of EDP was elucidated in the present work. First of all, the phase I biotransformation was stu...

A N aromatic (aro) mutant of Escherichia coli may demand for its growth tyrosine, phenylalanine, tryptophan, para-aminobenzoic acid, para-hydroxybenzoic acid and a sixth unknown factor, or only the first two, three, four or five of these (DAVIS 1952a). Biochemical analyses of the aromatic pathway by several workers have indicated the possible presence of seven sequential steps leading to choris...

234 CLINICAL CHEMISTRY, Vol. 32, No. 1, 1986 basic chemical principles. Reviewing uric acid methodology, we discovered one incorrect and two unbalanced reaction equations for uric acid analysis by the uricas&peroxidase-phenol-4-aminoantipyrine method. Figure 1 illustrates the overall reaction. An investigator has incorrectly prothe formation of a dichloro-oquinoneimine dye from the reaction bet...

Microorganisms that require p-aminobenzoic acid or compounds of the folic acid group may have either requirement replaced by a purine and thymine (or thymidine) and several amino acids or vitamin B12 (Lampen et al., 1949; Stokstad, 1941; Baker et al., 1955); the vitamins, p-aminobenzoic or folic acids, are believed necessary for the synthesis of those compounds which can bypass them (Shive, 195...

As part of an educational exercise designed to introduce school students the technique single-crystal X-ray diffraction and enhance their understanding primary secondary bonding, a group nine was given opportunity prepare new compounds solve refine data collected on crystalline materials they had prepared. Their investigation alkali metal salts 4-hydroxybenzoic acid (H 2 hba) yielded structures...

In defense of: • Glycerine (Page 4) • Cetyl Stearyl Alcohol (Page 5) • Animal Products (Beeswax, Lactic acid & Lanolin in one product each) (Page 5) • Para-aminobenzoic Acid (PABA) (Page 5) • Parabens (Page 6) o Hazardous and Useless Alternatives Exposed (Page 8) Silver Chloride (Page 8) Grapefruit Seed Extract [Adulterated with Benzethonium Chloride & Triclosan] (Page 8) In defense of: • Sodiu...

Acetylation as a means of detoxication is not very common. So far it has been observed in the case of amino compounds only (1). p-Aminobensoic acid, for example, is partially acetylated by the rabbit and eliminated as p-acetylaminobenzoic acid (2). It is conceivable that the acetyl group may be derived from carbohydrates, fats, or even proteins. In order to study this mechanism somewhat more in...

In the presented study, the HPLC method was used for the determination of impurities (p-aminobenzoic acid and p-aminobenzoyl-L-glutamic acid) in single-component pharmaceutical products containing folic acid. The determination was performed using a spectrophotometric detector at lambda = 269 nm wavelength.