Using combinatorial methods, we synthesized a series of new vinyl amide monomers and graft-polymerized them to light-sensitive poly(ether sulfone) (PES) porous films for protein resistance. To increase the discovery rate and statistical confidence, we developed high throughput surface modification methods (HTP) that allow synthesis, screening and selection of desirable monomers from a large lib...

We investigate the sensitivity of femtosecond Fourier transform two-dimensional infrared spectroscopy to protein secondary structure with a study of antiparallel beta-sheets. The results show that 2D IR spectroscopy is more sensitive to structural differences between proteins than traditional infrared spectroscopy, providing an observable that allows comparison to quantitative models of protein...

OBJECTIVE The aim of this study was to evaluate the effects of staining solutions on the color stability and roughness of different provisional resin material. MATERIAL AND METHODS Three different materials were tested (two polymethylmethacrylate and one bis-acryl composite resins) in cola and coffee and for 1 and 4 weeks. 240 specimens were used - half of them polished and other half not. Co...

Normal mode calculations have been carried out for parallel-chain 8-sheet structures. These include the parallel-chain pleated sheet of poly(L-alanine) and the parallel-chain rippled sheet of polyglycine. Dipole derivative coupling has been included for amide I and I1 modes, and the effects of parallel-sheet and antiparallel-sheet arrangements of varying separation have been examined for the po...

Biopolymers such as DNA store information in their chains using controlled sequences of monomers. Here we describe a non-natural information-containing macromolecule that can store and retrieve digital information. Monodisperse sequence-encoded poly(alkoxyamine amide)s were synthesized using an iterative strategy employing two chemoselective steps: the reaction of a primary amine with an acid a...

UV resonance Raman excitation profiles and Raman depolarization ratios were measured for trialanine and tetraalanine between 198 and 210 nm. Excitation within the pi --> pi* electronic transitions of the peptide bond results in UVRR spectra dominated by amide peptide bond vibrations. In addition to the resonance enhancement of the normal amide vibrations, we find enhancement of the symmetric te...