Nanoparticles composed of poly(alkyl cyanoacrylate) (PACA) have shown great promise due to their biodegradability and high drug loading capacity. Development optimal PACA nanocarriers requires detailed analysis the overall cellular impact exerted by variants. We here perform a comprehensive comparison cabazitaxel (CBZ)-loaded three different monomers, i.e. poly(n-butyl (PBCA), poly(2-ethylbutyl...

Abstract Insufficient osseointegration, inflammatory response and bacterial infection are responsible for the majority of bone implant failures. Drug-releasing implants subjected to adequate surface modification can concurrently address these challenges improve success surgeries. This work investigates use Ti-6Al-4V (Ti64) with a dual-scale topography as platform local drug delivery. Dual-scale...

This chapter is a summary of our work on the design of block copolymer micellar systems with improved solubilization capacity for poorly soluble aromatic drugs. The copolymers of interest are block copoly(oxyalkylene)s with linear dior triblock architecture which combine hydrophilic poly(ethylene oxide) with hydrophobic blocks formed from poly(propylene oxide), poly(1,2-butylene oxide), poly(st...

Stealth nanoparticles made of polymer micelles are ideal drug carriers for targeted drug delivery, but their stability is critical for intravenous applications. We found that core-surfacecrosslinked nanoparticles (SCNp) made from amphiphilic brush copolymers had greatly enhanced stability. The surface of the SCNps can be easily tailored by using different chains. The amphiphilic brush copolymer...

Abstract: Background: Chronic kidney disease is a longstanding which leads to gradual loss of function causing renal failure. Although medications are more effective, Increase in the number drugs can lead various drug related problems. Our study aims identify most common DRPs chronic patients. Materials and Methods: A prospective observational done Department Nephrology, PSG Hospital, Coimbator...

Near-infrared (NIR) light-triggered drug release systems are promising for drug delivery applications in view of the advantages of NIR light, which include high tissue penetration and low damage. In this report, we developed nanogels (NGs) by supramolecular self-assembly from adamantine (AD)-conjugated copolymer, poly[poly(ethylene glycol)monomethyl ether metharcylate]-co-poly(N-(2-hydroxypropy...

Although approved by the U.S. Food and Drug Administration, enfuvirtide is rarely used in combination antiretroviral therapies (cART) to treat HIV-1 infection, primarily because of its intense dosing schedule that requires twice-daily subcutaneous injection. Here, we describe the development of enfuvirtide-loaded, degradable poly(lactic-co-glycolic) acid microparticles that provide linear in vi...

Background: As chronic diseases require treatment with an expanding number of medications, the issue polypharmacy is getting more significant. Polypharmacy can lead to danger adverse events, drug interactions and medication non adherence. Objective: To improve patient compliance, check whether all drugs prescribed are safe appropriate use, knowledge about their medical state poly-pharmacy there...

Vesicles formed in water by synthetic macro-amphiphiles have attracted much attention as nanocontainers having properties that extend the physical and chemical limits of liposomes. We sought to develop ABA block copolymeric amphiphiles that self-assemble into unilamellar vesicles that can be further oxidatively destabilized. We selected poly(ethylene glycol) (PEG) as the hydrophilic A blocks, o...